K
Kamal D. Puri
Researcher at Icos
Publications - 67
Citations - 6494
Kamal D. Puri is an academic researcher from Icos. The author has contributed to research in topics: P110δ & Kinase. The author has an hindex of 38, co-authored 65 publications receiving 6036 citations. Previous affiliations of Kamal D. Puri include Harvard University & University of Washington.
Papers
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Journal ArticleDOI
CAL-101, a p110δ selective phosphatidylinositol-3-kinase inhibitor for the treatment of B-cell malignancies, inhibits PI3K signaling and cellular viability
Brian J. Lannutti,Sarah A. Meadows,Sarah E. M. Herman,Adam Kashishian,Bart Steiner,Amy J. Johnson,John C. Byrd,Jeffrey W. Tyner,Marc M. Loriaux,Mike Deininger,Brian J. Druker,Kamal D. Puri,Roger G. Ulrich,Neill A. Giese +13 more
TL;DR: Using tumor cell lines and primary patient samples representing multiple B-cell malignancies, it is demonstrated that constitutive phosphatidylinositol-3-kinase pathway activation is p110δ-dependent, providing a rationale for the ongoing clinical evaluation of CAL-101.
Journal ArticleDOI
Phosphatidylinositol 3-kinase-δ inhibitor CAL-101 shows promising preclinical activity in chronic lymphocytic leukemia by antagonizing intrinsic and extrinsic cellular survival signals.
Sarah E. M. Herman,Amber Gordon,Amy J. Wagner,Nyla A. Heerema,Weiqiang Zhao,Joseph M. Flynn,Jeffrey A. Jones,Leslie A. Andritsos,Kamal D. Puri,Brian Lannutti,Neill A. Giese,Xiaoli Zhang,Lai Wei,John C. Byrd,Amy J. Johnson +14 more
TL;DR: These studies provide rationale for the clinical development of CAL-101 as a first-in-class targeted therapy for CLL and related B-cell lymphoproliferative disorders.
Journal ArticleDOI
Structural Remodeling of the Human Colonic Mesenchyme in Inflammatory Bowel Disease
James Kinchen,Hannah Chen,Kaushal Parikh,Agne Antanaviciute,Marta Jagielowicz,David Fawkner-Corbett,Neil Ashley,Laura Cubitt,Esther Mellado-Gomez,Moustafa Attar,Eshita Sharma,Quin F. Wills,Rory Bowden,Felix Richter,David Ahern,Kamal D. Puri,Jill Henault,Francois Gervais,Hashem Koohy,Alison Simmons +19 more
TL;DR: This work defines how the colonic mesenchyme remodels to fuel inflammation and barrier dysfunction in IBD.
Journal ArticleDOI
The Kinetics of L-selectin Tethers and the Mechanics of Selectin-mediated Rolling
TL;DR: Shear uniquely enhances the rate of L-selectin transient tether formation, and conversion of tethers to rolling adhesions, providing further understanding of the shear threshold requirement for rolling through L- selectin.
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Platelet-mediated Lymphocyte Delivery to High Endothelial Venules
TL;DR: In vitro, activated platelets enhanced tethering of lymphocytes to PNAd and sustained lymphocyte rolling, even in the absence of functional L-selectin, provides a second mechanism for lymphocyte delivery to HEVs.