D
David Boutolleau
Researcher at Pierre-and-Marie-Curie University
Publications - 85
Citations - 1609
David Boutolleau is an academic researcher from Pierre-and-Marie-Curie University. The author has contributed to research in topics: Medicine & Herpes simplex virus. The author has an hindex of 20, co-authored 66 publications receiving 1312 citations. Previous affiliations of David Boutolleau include University of Paris & French Institute of Health and Medical Research.
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Journal ArticleDOI
Human Herpesvirus (HHV)–6 and HHV–7: Two Closely Related Viruses with Different Infection Profiles in Stem Cell Transplantation Recipients
David Boutolleau,Caroline Fernandez,Elisabeth Andre,Berthe-Marie Imbert-Marcille,Noel Milpied,Henri Agut,Agnès Gautheret-Dejean +6 more
TL;DR: Human herpesvirus (HHV)-6 and HHV-7 loads were evaluated retrospectively in peripheral blood mononuclear cells (PBMC) from 78 recipients of stem cell transplantation (SCT) by real-time polymerase chain reaction, and the kinetics of Roseolovirus loads during the posttransplantation period suggested that HHv-7 may act as a cofactor ofHHV-6 reactivation.
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Retrospective Observational Study of Brain MRI Findings in Patients with Acute SARS-CoV-2 Infection and Neurologic Manifestations.
Lydia Chougar,Natalia Shor,Nicolas Weiss,Damien Galanaud,Delphine Leclercq,Bertrand Mathon,Samia Belkacem,Sébastian Ströer,Sonia Burrel,David Boutolleau,Alexandre Demoule,Charlotte Rosso,Cécile Delorme,Danielle Seilhean,Didier Dormont,Elise Morawiec,Mathieu Raux,Sophie Demeret,Sophie Gerber,Stéphanie Trunet,Thomas Similowski,Vincent Degos,Pierre Rufat,Jean-Christophe Corvol,Stéphane Lehéricy,Nadya Pyatigorskaya +25 more
TL;DR: Two patterns including white matter enhancing lesions and basal ganglia abnormalities that could be related to SARS-CoV-2 infection are identified that are related to COVID-19 patients with neurological manifestations.
Journal ArticleDOI
Multicenter Comparison of PCR Assays for Detection of Human Herpesvirus 6 DNA in Serum
Louis Flamand,Annie Gravel,David Boutolleau,Roberto Alvarez-Lafuente,Steve Jacobson,Mauro S. Malnati,Debra Kohn,Yi-Wei Tang,Tetsushi Yoshikawa,Dharam V. Ablashi +9 more
TL;DR: It is proposed that investigators interested in quantifying HHV-6 in clinical samples adopt one of these assays, and three TaqMan-based real-time PCR assays yielded quantities that were closest to the quantity of HHv-6 that had been spiked.
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Identification of human herpesvirus 6 variants A and B by primer-specific real-time PCR may help to revisit their respective role in pathology
David Boutolleau,C. Duros,Pascale Bonnafous,Delphine Caïola,Alexandre Karras,Nathalie De Castro,Marie Ouachée,Philippe Narcy,Marie Gueudin,Henri Agut,Agnès Gautheret-Dejean +10 more
TL;DR: The wide prevalence of HHV-6B is confirmed and the potential greater neuropathogenic role of HHv-6A is highlighted in immunocompromised patients and young infants, and a new real-time variant-specific PCR method is developed, able to differentiate both variants in biological samples, even in the case of mixed infections.
Journal ArticleDOI
Human herpesvirus-6 (HHV-6) DNA in plasma reflects the presence of infected blood cells rather than circulating viral particles.
Abla Achour,David Boutolleau,Amine Slim,Henri Agut,Agnès Gautheret-Dejean,Agnès Gautheret-Dejean +5 more
TL;DR: Data tend to favour the hypothesis of a release of HHV-6 and cellular DNA into plasma following the lysis of infected PBMCs, as well as in corresponding peripheral blood mononuclear cells (PBMCs) using specific real-time PCR.