David Briand

TL;DR: Although in all models the muscle regenerates completely, the trajectories of the regenerative process vary considerably, and it is shown that histological parameters are not wholly sufficient to declare that regeneration is complete as molecular alterations could have a major persistent impact.

TL;DR: It is shown that mitochondrial and metabolic alterations underlie the sepsis-induced long-term impairment of satellite cells and lead to inefficient muscle regeneration, and that Engrafting mesenchymal stem cells improves the septic status by decreasing cytokine levels, restoring mitochondria and metabolic function in satellite cells, and improving muscle strength.

TL;DR: MuscleJ markedly enhances statistical analysis by allowing reliable comparison of skeletal muscle physiology-pathology results obtained from different laboratories using different acquisition systems, and is available as a free tool for the skeletal muscle community.

TL;DR: It is demonstrated that the microvascular system is almost normal in young-adult in contrast to old mdx mice, displaying marked microvessel alterations, and the functional repercussions on muscle perfusion and bioenergetics after a hypoxic stress vary depending on stage of pathology.

TL;DR: In a murine model of severe sepsis, micro‐fragmented fat improved early inflammatory status and outcome, at least in part, by a cyclo‐oxygenase‐2‐mediated mechanism.