D
David C. U'Prichard
Researcher at Northwestern University
Publications - 26
Citations - 1438
David C. U'Prichard is an academic researcher from Northwestern University. The author has contributed to research in topics: Receptor & Adrenergic receptor. The author has an hindex of 16, co-authored 26 publications receiving 1435 citations. Previous affiliations of David C. U'Prichard include Florida State University College of Arts and Sciences & Wilmington University.
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Journal ArticleDOI
Modulation of rat brain α- and β-adrenergic receptor populations by lesions of the dorsal noradrenergic bundle
David C. U'Prichard,David C. U'Prichard,David C. U'Prichard,Terry D. Reisine,Terry D. Reisine,Terry D. Reisine,Stephen T. Mason,Stephen T. Mason,Stephen T. Mason,Hans C. Fibiger,Hans C. Fibiger,Hans C. Fibiger,Henry I. Yamamura,Henry I. Yamamura,Henry I. Yamamura +14 more
TL;DR: Bilateral lesion of the ascending noradrenergic fibers in the dorsal bundle of adult Wistar rats with 4 μg 6-hydroxydopamine caused extensive depletion of norepinephrine in all forebrain areas, but led to a 54% increase in nore Pinephrine levels in the cerebellum.
Book ChapterDOI
Characterization of alpha 1- and alpha 2-adrenergic receptors.
TL;DR: In this paper, it was shown that α2 receptors may exist in multiple-affinity states reflecting the ability of the α2 binding-site protein to form a complex with additional membrane proteins that themselves are receptors for the physiological substrates guanosine 5'-triphosphate (GTP), Na+, Mg2+, and possibly Ca2+-calmodulin.
Journal ArticleDOI
Differential effects of antidepressant treatment on brain monoaminergic receptors.
TL;DR: In vitro experiments indicated that antidepressants are relatively weak alpha 2-receptor blocking agents, but some are potent on the alpha 1-recept system indicating that the norepinephrine releasing potency of some antidepressants may not be mediated by blockade of presynaptic autoreceptors.
Journal ArticleDOI
Human platelet α2-adrenergic receptors: Labeling with 3H-yohimbine, a selective antagonist ligand
Makoto Daiguji,Makoto Daiguji,Herbert Y. Meltzer,Herbert Y. Meltzer,David C. U'Prichard,David C. U'Prichard +5 more
TL;DR: 3 H-Yohimbine labeled fewer platelet sites than did 3 H-dihydroergocryptine under identical conditions, and may be a more specific and useful antagonist probe of platelet α 2 -receptors than 3 H. dihydrocryptine.
Journal ArticleDOI
beta-Adrenergic regulation of alpha 2-adrenergic receptors in the central nervous system
TL;DR: The beta-mediated regulation of alpha 2-receptor sensitivity at brain norepinephrine synapses may be a mechanism for the homeostatic control of central noradrenergic activity.