Showing papers in "European Journal of Pharmacology in 1980"

TL;DR: A simple, rapid technique for intrathecal injections by lumbar puncture in unanesthetized mice is described, and submicrogram quantities of morphine sulfate induced Straub tail response and tail-flick analgesia.

TL;DR: An examination of cells collected by washing the peritoneum revealed a large decrease between 15 and 30 min after injection of the irritant, which suggested that the prostaglandins could be produced by neutrophil polynuclear cells but also by destruction of macrophages.

TL;DR: The pharmacological properties of PAF-acether are compatible with its proposed role in the bronchoconstriction of asthma which is probably caused by a still unidentified factor.

TL;DR: Some non-steroid anti-inflammatory drugs which inhibit arachidonate cyclo-oxygenease have been examined for their effects on leukocyte migration, prostaglandin production and oedema formation in carrageenin-induced inflammation in the rat.

TL;DR: It is concluded that these 3H-imipramine binding sites may be important in the study of depression and of the mechanism of action of antidepressant drugs.

TL;DR: In vitro experiments indicated that antidepressants are relatively weak alpha 2-receptor blocking agents, but some are potent on the alpha 1-recept system indicating that the norepinephrine releasing potency of some antidepressants may not be mediated by blockade of presynaptic autoreceptors.

TL;DR: In this paper, single cell recordings from noradrenergic neurons of the locus coeruleus (LC) show that after one week of desipramine treatment, neuronal firing rate is lower than in control rats but greater than that seen in response to acutely administered drug.

TL;DR: The results are not compatible with the existence of a single α-adrenoceptor type at both pre- and postsynaptic receptor sites and can be explained by the assumption of 2 receptor subtypes pre- as well as postsynaptically (α1, α2).

TL;DR: The results obtained suggest a subclassification of postsynaptic alpha-adrenoceptors into alpha 1- and alpha 2-subtypes mediating pressor effects, and yohimbine an antagonist of post Synaptic alpha 2 -adrenOceptors and phentolamine behaves as a non-selective antagonist.

TL;DR: 3,4-Diaminopyridine, like 4-AP, converted the end-plate potential produced by electronic depolarization of tetrodotoxin-blocked frog nerve terminals into an all-or-none response, implying that the drugs enhance transmitter release by greatly increasing the voltage-dependent calcium conductance of the nerve terminal membrane.

TL;DR: Estrogen treatment increased the number of dopamine receptor sites labeled by [3H]spiroperidol in vitro and the intensity of stereotypy induced by dopamine agonists in vivo, and these two measures suggest that estrogen administration significantly influences thenumber of striatal DA receptors and a response to in vivo striatalDA receptor stimulation.

TL;DR: The findings indicate that the mechanism of the inhibitory action ofadenosine and adenine nucleotides is different from that of conventional inhibitory neurotransmitters such as gamma-aminobutyric acid and suggest a presynaptic action of adenosine

TL;DR: A new method for extraction of immunoreactive substance P (I-SP) from rat intestine including pulverization of tissue frozen in liquid nitrogen and extraction with acid acetone is described, indicating that intrinsic SP neurones are capsaicin-insensitive.

TL;DR: It is suggested that the decrease in the firing of LC cells plays a major role in the increased firing of hippocampal cells obtained after desipramine treatment.

TL;DR: The results indicate that GABA stimulates receptor mediating excitation of cholinergic excitatory and enteric inhibitory neurons whereas it has littel or no direct effect on the muscle of the ileum or distal colon.

TL;DR: The hypothesis that somatostatin may function as a neurotransmitter in the central nervous system is supported, as the results indicated that SRIF does not evoke the excitatory responses through attenuation of GABA-mediated inhibition.

TL;DR: Evidence of biochemical changes which parallel the behavioural findings of enhanced dopamine receptor activity that occur during continuous long-term neuroleptic administration to rodents is provided.

TL;DR: It is concluded that amrinone causes a nonspecific inhibition of smooth muscle contractility by acting probably at multiple sites to decrease the availability of Ca2+ required for activation.

TL;DR: High doses of apomorphine induced increases in matrix crossings and locomomtor movements at all ages tested and induced wall climbing behavior in 7 and 14 day olds, but not older animals.

TL;DR: The behavioural and biochemical components of the supersensitivity show variable time courses and in particular the enhanced stimulation of striatal adenylate cyclase persists for at least 6 months and may be of relevance to tardive dyskinesias in man.

TL;DR: Iminoimidazolidine clonidine reduced concentration-dependently the release of 3H-noradrenaline evoked by electrical stimulation from the rate cerebral cortex and antagonized selectively the presynaptic inhibitory effects of imidazolines on alpha 2-adrenoceptors.

TL;DR: It is demonstrated that chronic treatment with antidepressant drugs leads to a postsynaptic subsensitivity of cortical neurons to NE, and these cingulate neurons to GABA was unchanged after Chronic treatment with the antidepressant drugs.

TL;DR: Co-administration of yohimbine was found to accelerate the time course and increase the magnitude of desipramine-induced increases in [3H]clonidine binding and the possible physiologic significance of these findings is discussed along with their pharmacologic implications.

TL;DR: It is reported that 3H-beta-EP binding is saturable, stereospecific, has high affinity and is inhibited by sodium, and its dissociation rate is ten-fold longer than that of naloxone.

TL;DR: It is tentatively suggested that the inhibitory effect of NA on 3H-5-HT release from hippocampus slices reflects the activation of postsynaptic alpha-receptors which are localized on serotonergic nerve terminals.

TL;DR: It is concluded that captopril inhibits angiotensin-converting enzyme activity in the brain even when given subcutaneously or by gavage in doses commonly used in the rat.

TL;DR: Almitrine slightly stimulated ventilation in dogs with bilateral section of carotid sinus nerves and aortic nerves and this disappeared when both vagus nerves were cut indicating that this effect was mediated through some chemoreceptor fibres present in thevagus nerves or through afferent vagal fibres.