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David Chu
Researcher at Johns Hopkins University School of Medicine
Publications - 93
Citations - 4234
David Chu is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Cancer & Breast cancer. The author has an hindex of 37, co-authored 87 publications receiving 3782 citations. Previous affiliations of David Chu include Cedars-Sinai Medical Center & City of Hope National Medical Center.
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Journal ArticleDOI
Detection of cancer DNA in plasma of patients with early-stage breast cancer.
Julia A. Beaver,Danijela Jelovac,Sasidharan Balukrishna,Rory L. Cochran,Sarah Croessmann,Daniel J. Zabransky,Hong Yuen Wong,Patricia Valda Toro,Justin Cidado,Brian G. Blair,David Chu,Timothy F. Burns,Michaela J. Higgins,Vered Stearns,Lisa K. Jacobs,Mehran Habibi,Julie R. Lange,Paula J. Hurley,Josh Lauring,Dustin A. VanDenBerg,Jill Kessler,Stacie Jeter,Michael L. Samuels,Dianna Maar,Leslie Cope,Ashley Cimino-Mathews,Pedram Argani,Antonio C. Wolff,Ben Ho Park +28 more
TL;DR: This prospective study demonstrates accurate mutation detection in tumor tissues using ddPCR, and that ptDNA can be detected in blood before and after surgery in patients with early-stage breast cancer.
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Contralateral prophylactic mastectomy improves the outcome of selected patients undergoing mastectomy for breast cancer
Elizabeth A. Peralta,Joshua D. I. Ellenhorn,Lawrence D. Wagman,Andrew Dagis,James S. Andersen,David Chu +5 more
TL;DR: CPM prevented CBC and significantly prolonged disease-free survival and future studies will need to address risk assessment and contralateral breast cancer prevention in patients treated for early breast cancer.
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Quality of life outcomes in 599 cancer and non-cancer patients with colostomies.
TL;DR: While patients with cancer had a better overall QOL than those with benign processes, concerns were common to all colostomy patients, and health care practitioners should consider discussing QOL concerns during pre-operation treatment decisions and post operative teaching and follow-up care.
Journal ArticleDOI
ESR1 mutations in circulating plasma tumor DNA from metastatic breast cancer patients
David Chu,Costanza Paoletti,Christina L. Gersch,Dustin A. VanDenBerg,Daniel J. Zabransky,Rory L. Cochran,Hong Yuen Wong,Patricia Valda Toro,Justin Cidado,Sarah Croessmann,Bracha Erlanger,Karen Cravero,Kelly Kyker-Snowman,Berry Button,Heather A. Parsons,W. Brian Dalton,Riaz Gillani,Arielle Medford,Kimberly Aung,Nahomi Tokudome,Arul M. Chinnaiyan,Anne F. Schott,Dan R. Robinson,Karen S. Jacks,Josh Lauring,Paula J. Hurley,Daniel F. Hayes,James M. Rae,Ben Ho Park,Ben Ho Park +29 more
TL;DR: A high frequency of ESR1 mutations is shown using circulating plasma tumor DNA (ptDNA) from patients with metastatic breast cancer and it is suggested that blood can be used to identify additional mutations not found by sequencing of a single metastatic lesion.
Journal ArticleDOI
Revision and Psychometric Testing of the City of Hope Quality of Life–Ostomy Questionnaire
TL;DR: Evidence is provided for the validity and reliability of the COH-QOL-Ostomy Questionnaire as a comprehensive, multidimensional self-report questionnaire for measuring quality of life in patients with intestinal ostomies.