J
Josh Lauring
Researcher at Johns Hopkins University
Publications - 50
Citations - 3172
Josh Lauring is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 26, co-authored 45 publications receiving 2714 citations. Previous affiliations of Josh Lauring include Janssen Pharmaceutica & Johns Hopkins University School of Medicine.
Papers
More filters
Journal ArticleDOI
NSD2 Links Dimethylation of Histone H3 at Lysine 36 to Oncogenic Programming
Alex J. Kuo,Peggie Cheung,Kaifu Chen,Barry M. Zee,Mitomu Kioi,Josh Lauring,Yuanxin Xi,Ben Ho Park,Xiaobing Shi,Benjamin A. Garcia,Wei Li,Or Gozani +11 more
TL;DR: It is shown that dimethylation of histone H3 at lysine 36 (H3K36me2) is the principal chromatin-regulatory activity of N SD2 and that genomic disorganization of this canonical chromatin mark by NSD2 initiates oncogenic programming.
Journal ArticleDOI
Detection of cancer DNA in plasma of patients with early-stage breast cancer.
Julia A. Beaver,Danijela Jelovac,Sasidharan Balukrishna,Rory L. Cochran,Sarah Croessmann,Daniel J. Zabransky,Hong Yuen Wong,Patricia Valda Toro,Justin Cidado,Brian G. Blair,David Chu,Timothy F. Burns,Michaela J. Higgins,Vered Stearns,Lisa K. Jacobs,Mehran Habibi,Julie R. Lange,Paula J. Hurley,Josh Lauring,Dustin A. VanDenBerg,Jill Kessler,Stacie Jeter,Michael L. Samuels,Dianna Maar,Leslie Cope,Ashley Cimino-Mathews,Pedram Argani,Antonio C. Wolff,Ben Ho Park +28 more
TL;DR: This prospective study demonstrates accurate mutation detection in tumor tissues using ddPCR, and that ptDNA can be detected in blood before and after surgery in patients with early-stage breast cancer.
Journal ArticleDOI
Phosphoinositide 3-Kinase Regulates Glycolysis through Mobilization of Aldolase from the Actin Cytoskeleton
Hai Hu,Ashish Juvekar,Costas A. Lyssiotis,Evan C. Lien,John G. Albeck,Doogie Oh,Gopal Varma,Yin P Hung,Soumya Ullas,Josh Lauring,Pankaj Seth,Mark R. Lundquist,Dean R. Tolan,Aaron K. Grant,Daniel J. Needleman,John M. Asara,Lewis C. Cantley,Gerburg M. Wulf +17 more
TL;DR: A master regulatory function of PI3K is pointed toward that integrates an epithelial cell's metabolism and its form, shape, and function, coordinating glycolysis with the energy-intensive dynamics of actin remodeling.
Journal ArticleDOI
A conserved transcriptional enhancer regulates RAG gene expression in developing B cells.
Lih Yun Hsu,Josh Lauring,Hong Erh Liang,Stephen Greenbaum,Dragana Cado,Yuan Zhuang,Mark S. Schlissel +6 more
TL;DR: It is concluded that RAG transcription is regulated by distinct elements in developing B and T cells and that Erag is required for optimal levels of RAG expression in early B cell precursors but not in T cells.
Journal ArticleDOI
ESR1 mutations in circulating plasma tumor DNA from metastatic breast cancer patients
David Chu,Costanza Paoletti,Christina L. Gersch,Dustin A. VanDenBerg,Daniel J. Zabransky,Rory L. Cochran,Hong Yuen Wong,Patricia Valda Toro,Justin Cidado,Sarah Croessmann,Bracha Erlanger,Karen Cravero,Kelly Kyker-Snowman,Berry Button,Heather A. Parsons,W. Brian Dalton,Riaz Gillani,Arielle Medford,Kimberly Aung,Nahomi Tokudome,Arul M. Chinnaiyan,Anne F. Schott,Dan R. Robinson,Karen S. Jacks,Josh Lauring,Paula J. Hurley,Daniel F. Hayes,James M. Rae,Ben Ho Park,Ben Ho Park +29 more
TL;DR: A high frequency of ESR1 mutations is shown using circulating plasma tumor DNA (ptDNA) from patients with metastatic breast cancer and it is suggested that blood can be used to identify additional mutations not found by sequencing of a single metastatic lesion.