P
Patricia Valda Toro
Researcher at Yale University
Publications - 15
Citations - 729
Patricia Valda Toro is an academic researcher from Yale University. The author has contributed to research in topics: Pneumonia & Breast cancer. The author has an hindex of 9, co-authored 12 publications receiving 603 citations. Previous affiliations of Patricia Valda Toro include University of California, San Francisco & Johns Hopkins University School of Medicine.
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Journal ArticleDOI
Detection of cancer DNA in plasma of patients with early-stage breast cancer.
Julia A. Beaver,Danijela Jelovac,Sasidharan Balukrishna,Rory L. Cochran,Sarah Croessmann,Daniel J. Zabransky,Hong Yuen Wong,Patricia Valda Toro,Justin Cidado,Brian G. Blair,David Chu,Timothy F. Burns,Michaela J. Higgins,Vered Stearns,Lisa K. Jacobs,Mehran Habibi,Julie R. Lange,Paula J. Hurley,Josh Lauring,Dustin A. VanDenBerg,Jill Kessler,Stacie Jeter,Michael L. Samuels,Dianna Maar,Leslie Cope,Ashley Cimino-Mathews,Pedram Argani,Antonio C. Wolff,Ben Ho Park +28 more
TL;DR: This prospective study demonstrates accurate mutation detection in tumor tissues using ddPCR, and that ptDNA can be detected in blood before and after surgery in patients with early-stage breast cancer.
Journal ArticleDOI
ESR1 mutations in circulating plasma tumor DNA from metastatic breast cancer patients
David Chu,Costanza Paoletti,Christina L. Gersch,Dustin A. VanDenBerg,Daniel J. Zabransky,Rory L. Cochran,Hong Yuen Wong,Patricia Valda Toro,Justin Cidado,Sarah Croessmann,Bracha Erlanger,Karen Cravero,Kelly Kyker-Snowman,Berry Button,Heather A. Parsons,W. Brian Dalton,Riaz Gillani,Arielle Medford,Kimberly Aung,Nahomi Tokudome,Arul M. Chinnaiyan,Anne F. Schott,Dan R. Robinson,Karen S. Jacks,Josh Lauring,Paula J. Hurley,Daniel F. Hayes,James M. Rae,Ben Ho Park,Ben Ho Park +29 more
TL;DR: A high frequency of ESR1 mutations is shown using circulating plasma tumor DNA (ptDNA) from patients with metastatic breast cancer and it is suggested that blood can be used to identify additional mutations not found by sequencing of a single metastatic lesion.
Journal ArticleDOI
Comparison of cell stabilizing blood collection tubes for circulating plasma tumor DNA
Patricia Valda Toro,Bracha Erlanger,Julia A. Beaver,Rory L. Cochran,Dustin A. VanDenBerg,Elizabeth Yakim,Karen Cravero,David Chu,Daniel J. Zabransky,Hong Yuen Wong,Sarah Croessmann,Heather A. Parsons,Paula J. Hurley,Josh Lauring,Ben Ho Park,Ben Ho Park +15 more
TL;DR: It is concluded that BCT tubes can prevent lysis and cellular release of genomic DNA of blood samples from cancer patients when stored at room temperature, and could therefore be of benefit for blood specimen collections in clinical trials.
Journal ArticleDOI
Severe respiratory viral infection induces procalcitonin in the absence of bacterial pneumonia.
Samir Gautam,Avi J. Cohen,Yannick Stahl,Patricia Valda Toro,Grant Young,Rupak Datta,Xiting Yan,Nicholas Ristic,Santos Bermejo,Lokesh Sharma,Marcos I. Restrepo,Charles S. Dela Cruz +11 more
TL;DR: It is revealed that procalcitonin rises during pure viral infection in proportion to disease severity and is not suppressed by interferon signalling, in contrast to prior models of procalCitonin regulation.
Journal ArticleDOI
Genetic Alterations Detected in Cell-Free DNA Are Associated With Enzalutamide and Abiraterone Resistance in Castration-Resistant Prostate Cancer.
Samantha Torquato,Aparna Pallavajjala,Alexa Goldstein,Patricia Valda Toro,John L. Silberstein,Justin Lee,Mary Nakazawa,Ian Waters,David Chu,Daniel Shinn,Taylor Groginski,Robert M. Hughes,Brian W. Simons,Hamda Khan,Zhaoyong Feng,Michael A. Carducci,Channing J. Paller,Samuel R. Denmeade,Bruce Kressel,Mario A. Eisenberger,Emmanuel S. Antonarakis,Bruce J. Trock,Ben Ho Park,Paula J. Hurley +23 more
TL;DR: Findings support the conclusion that high circulating tumor DNA burden is associated with worse outcomes to enzalutamide and abiraterone in men with mCRPC.