R
Rory L. Cochran
Researcher at Harvard University
Publications - 32
Citations - 1381
Rory L. Cochran is an academic researcher from Harvard University. The author has contributed to research in topics: Breast cancer & Carcinogenesis. The author has an hindex of 15, co-authored 32 publications receiving 1150 citations. Previous affiliations of Rory L. Cochran include University of Montana & Johns Hopkins University School of Medicine.
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Journal ArticleDOI
Detection of cancer DNA in plasma of patients with early-stage breast cancer.
Julia A. Beaver,Danijela Jelovac,Sasidharan Balukrishna,Rory L. Cochran,Sarah Croessmann,Daniel J. Zabransky,Hong Yuen Wong,Patricia Valda Toro,Justin Cidado,Brian G. Blair,David Chu,Timothy F. Burns,Michaela J. Higgins,Vered Stearns,Lisa K. Jacobs,Mehran Habibi,Julie R. Lange,Paula J. Hurley,Josh Lauring,Dustin A. VanDenBerg,Jill Kessler,Stacie Jeter,Michael L. Samuels,Dianna Maar,Leslie Cope,Ashley Cimino-Mathews,Pedram Argani,Antonio C. Wolff,Ben Ho Park +28 more
TL;DR: This prospective study demonstrates accurate mutation detection in tumor tissues using ddPCR, and that ptDNA can be detected in blood before and after surgery in patients with early-stage breast cancer.
Journal ArticleDOI
ESR1 mutations in circulating plasma tumor DNA from metastatic breast cancer patients
David Chu,Costanza Paoletti,Christina L. Gersch,Dustin A. VanDenBerg,Daniel J. Zabransky,Rory L. Cochran,Hong Yuen Wong,Patricia Valda Toro,Justin Cidado,Sarah Croessmann,Bracha Erlanger,Karen Cravero,Kelly Kyker-Snowman,Berry Button,Heather A. Parsons,W. Brian Dalton,Riaz Gillani,Arielle Medford,Kimberly Aung,Nahomi Tokudome,Arul M. Chinnaiyan,Anne F. Schott,Dan R. Robinson,Karen S. Jacks,Josh Lauring,Paula J. Hurley,Daniel F. Hayes,James M. Rae,Ben Ho Park,Ben Ho Park +29 more
TL;DR: A high frequency of ESR1 mutations is shown using circulating plasma tumor DNA (ptDNA) from patients with metastatic breast cancer and it is suggested that blood can be used to identify additional mutations not found by sequencing of a single metastatic lesion.
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Mutation of a single allele of the cancer susceptibility gene BRCA1 leads to genomic instability in human breast epithelial cells
Hiroyuki Konishi,Morassa Mohseni,Akina Tamaki,Joseph P. Garay,Sarah Croessmann,Sivasundaram Karnan,Akinobu Ota,Hong Yuen Wong,Yuko Konishi,Yuko Konishi,Bedri Karakas,Khola Tahir,Abde M. Abukhdeir,John P. Gustin,Justin Cidado,Grace M. Wang,David Cosgrove,Rory L. Cochran,Danijela Jelovac,Michaela J. Higgins,Sabrina Arena,Sabrina Arena,Lauren Hawkins,Josh Lauring,Amy L. Gross,Christopher M. Heaphy,Yositaka Hosokawa,Edward Gabrielson,Alan K. Meeker,Kala Visvanathan,Pedram Argani,Kurtis E. Bachman,Ben Ho Park +32 more
TL;DR: It is shown that heterozygous BRCA1 inactivation results in genomic instability in nontumorigenic human breast epithelial cells in vitro and in vivo, and B RCA1 haploinsufficiency may accelerate hereditary breast carcinogenesis by facilitating additional genetic alterations.
Journal ArticleDOI
Comparison of cell stabilizing blood collection tubes for circulating plasma tumor DNA
Patricia Valda Toro,Bracha Erlanger,Julia A. Beaver,Rory L. Cochran,Dustin A. VanDenBerg,Elizabeth Yakim,Karen Cravero,David Chu,Daniel J. Zabransky,Hong Yuen Wong,Sarah Croessmann,Heather A. Parsons,Paula J. Hurley,Josh Lauring,Ben Ho Park,Ben Ho Park +15 more
TL;DR: It is concluded that BCT tubes can prevent lysis and cellular release of genomic DNA of blood samples from cancer patients when stored at room temperature, and could therefore be of benefit for blood specimen collections in clinical trials.
Journal ArticleDOI
Ki-67 is required for maintenance of cancer stem cells but not cell proliferation
Justin Cidado,Justin Cidado,Hong Yuen Wong,D. Marc Rosen,Ashley Cimino-Mathews,Joseph P. Garay,Abigail G. Fessler,Zeshaan A. Rasheed,Jessica L. Hicks,Rory L. Cochran,Sarah Croessmann,Daniel J. Zabransky,Morassa Mohseni,Morassa Mohseni,Julia A. Beaver,David Chu,Karen Cravero,Eric S. Christenson,Arielle Medford,Austin Mattox,Angelo M. De Marzo,Pedram Argani,Ajay Chawla,Paula J. Hurley,Josh Lauring,Ben Ho Park,Ben Ho Park +26 more
TL;DR: It is demonstrated that genetic disruption of Ki-67 in human epithelial breast and colon cancer cells depletes the cancer stem cell niche, and Immunohistochemical analyses of human breast cancers revealed that Ki- 67 expression is maintained at equivalent or greater levels in metastatic sites of disease compared to matched primary tumors, suggesting that maintenance of Ki -67 expression is associated with metastatic/clonogenic potential.