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David Dankort
Researcher at McGill University
Publications - 43
Citations - 4572
David Dankort is an academic researcher from McGill University. The author has contributed to research in topics: Receptor tyrosine kinase & Melanoma. The author has an hindex of 25, co-authored 42 publications receiving 4194 citations. Previous affiliations of David Dankort include University of California, San Francisco & McMaster University.
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Journal ArticleDOI
BrafV600E cooperates with Pten loss to induce metastatic melanoma
David Dankort,David P. Curley,Robert A. Cartlidge,Betsy Nelson,Anthony N. Karnezis,William Damsky,Mingjian James You,Ronald A. DePinho,Martin McMahon,Marcus Bosenberg,Marcus Bosenberg +10 more
TL;DR: These mice, engineered with a common genetic profile to human melanoma, provide a system to study melanoma's cardinal feature of metastasis and for preclinical evaluation of agents designed to prevent or treat metastatic disease.
Journal ArticleDOI
A new mouse model to explore the initiation, progression, and therapy of BRAFV600E-induced lung tumors
TL;DR: BRaf(CA) mice infected with an Adenovirus expressing Cre recombinase developed benign lung tumors that only rarely progressed to adenocarcinoma and BRaf(VE)-induced lung tumors were prevented by pharmacological inhibition of MEK1/2.
Journal ArticleDOI
β-Catenin Signaling Controls Metastasis in Braf-Activated Pten-Deficient Melanomas
William Damsky,William Damsky,David P. Curley,David P. Curley,Manjula Santhanakrishnan,Lara E. Rosenbaum,James T. Platt,Bonnie E. Gould Rothberg,Makoto Mark Taketo,David Dankort,David L. Rimm,Martin McMahon,Marcus Bosenberg +12 more
TL;DR: In this article, β-catenin levels control tumor differentiation and regulate both MAPK/Erk and PI3K/Akt signaling in melanoma, which is a central mediator of melanoma metastasis to lymph nodes and lungs.
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A Central Role for RAF→MEK→ERK Signaling in the Genesis of Pancreatic Ductal Adenocarcinoma
Eric A. Collisson,Christy L. Trejo,Jillian M. Silva,Shenda Gu,James E. Korkola,Laura M. Heiser,Roch-Philippe Charles,Brian Rabinovich,Byron Hann,David Dankort,Paul T. Spellman,Wayne A. Phillips,Joe W. Gray,Martin McMahon +13 more
TL;DR: It is shown that expression of BRAF(V600E), but not PIK3CA(H1047R), in the mouse pancreas leads to pancreatic intraepithelial neoplasia (PanIN) lesions, and RAF→MEK→ERK signaling is central to the initiation and maintenance of PDA and to rational combination strategies in this disease.
Journal ArticleDOI
Abrogation of BRAFV600E-induced senescence by PI3K pathway activation contributes to melanomagenesis
Liesbeth C.W. Vredeveld,Patricia A. Possik,Marjon A. Smit,Katrin Meissl,Chrysiis Michaloglou,Hugo M. Horlings,Abderrahim Ajouaou,Pim C. Kortman,David Dankort,Martin McMahon,Wolter J. Mooi,Daniel S. Peeper +11 more
TL;DR: It is shown here that PTEN depletion abrogates BRAF(V600E)-induced senescence in human fibroblasts and melanocytes, and demonstrated that PI3K pathway activation serves as a rate-limiting event in this setting, acting at least in part by abrogating OIS.