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William Damsky
Researcher at Yale University
Publications - 129
Citations - 5028
William Damsky is an academic researcher from Yale University. The author has contributed to research in topics: Medicine & Melanoma. The author has an hindex of 26, co-authored 82 publications receiving 3209 citations. Previous affiliations of William Damsky include University of Vermont.
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Journal ArticleDOI
BrafV600E cooperates with Pten loss to induce metastatic melanoma
David Dankort,David P. Curley,Robert A. Cartlidge,Betsy Nelson,Anthony N. Karnezis,William Damsky,Mingjian James You,Ronald A. DePinho,Martin McMahon,Marcus Bosenberg,Marcus Bosenberg +10 more
TL;DR: These mice, engineered with a common genetic profile to human melanoma, provide a system to study melanoma's cardinal feature of metastasis and for preclinical evaluation of agents designed to prevent or treat metastatic disease.
Journal ArticleDOI
β-Catenin Signaling Controls Metastasis in Braf-Activated Pten-Deficient Melanomas
William Damsky,William Damsky,David P. Curley,David P. Curley,Manjula Santhanakrishnan,Lara E. Rosenbaum,James T. Platt,Bonnie E. Gould Rothberg,Makoto Mark Taketo,David Dankort,David L. Rimm,Martin McMahon,Marcus Bosenberg +12 more
TL;DR: In this article, β-catenin levels control tumor differentiation and regulate both MAPK/Erk and PI3K/Akt signaling in melanoma, which is a central mediator of melanoma metastasis to lymph nodes and lungs.
Journal ArticleDOI
JAK inhibitors in dermatology: The promise of a new drug class
William Damsky,Brett A. King +1 more
TL;DR: Evidence suggests that JAK inhibition might be broadly useful in dermatology, with early reports of efficacy in several other conditions, and JAK inhibitors can be administered orally or used topically and represent a promising new class of medications.
Journal ArticleDOI
T cell-induced CSF1 promotes melanoma resistance to PD1 blockade.
Natalie J. Neubert,Martina Schmittnaegel,Natacha Bordry,Sina Nassiri,Noémie Wald,Christophe Martignier,Laure Tillé,Krisztian Homicsko,Krisztian Homicsko,William Damsky,Hélène Maby-El Hajjami,Irina Klaman,Esther Danenberg,Kalliopi Ioannidou,Lana E. Kandalaft,George Coukos,Sabine Hoves,Carola Ries,Silvia A. Fuertes Marraco,Periklis G. Foukas,Michele De Palma,Daniel E. Speiser +21 more
TL;DR: The biology of hurdles that still need to be overcome in immunotherapy are uncovered, and simultaneous CSF1R targeting may be beneficial in melanomas refractory to immune checkpoint blockade and, possibly, other T cell–based therapies.
Journal ArticleDOI
A neutrophil activation signature predicts critical illness and mortality in COVID-19.
Matthew L Meizlish,Alexander B Pine,Jason Bishai,George Goshua,Emily R. Nadelmann,Michael Simonov,C-Hong Chang,Hanming Zhang,Marcus Shallow,Parveen Bahel,Kent A. Owusu,Yu Yamamoto,Tanima Arora,Deepak Atri,Amisha Patel,Rana Gbyli,Jennifer M. Kwan,Christine Won,Charles S. Dela Cruz,Christina Price,Jonathan L. Koff,Brett King,Henry M. Rinder,F. Perry Wilson,John Hwa,Stephanie Halene,William Damsky,David van Dijk,Alfred Ian Lee,Hyung J. Chun +29 more
TL;DR: In this paper, the authors carried out proteomic profiling of plasma from cross-sectional and longitudinal cohorts of hospitalized patients with COVID-19 and analyzed clinical data from a health system database of more than 3300 patients.