D
David DeTomaso
Researcher at Johns Hopkins University Applied Physics Laboratory
Publications - 5
Citations - 502
David DeTomaso is an academic researcher from Johns Hopkins University Applied Physics Laboratory. The author has contributed to research in topics: Gene & Solar wind. The author has an hindex of 2, co-authored 2 publications receiving 335 citations.
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Journal ArticleDOI
Solar Wind Electrons Alphas and Protons (SWEAP) Investigation: Design of the Solar Wind and Coronal Plasma Instrument Suite for Solar Probe Plus
Justin C. Kasper,Justin C. Kasper,R. Abiad,Gerry Austin,Marianne Balat-Pichelin,Stuart D. Bale,John W. Belcher,Peter Berg,Henry Bergner,Matthieu Berthomier,Jay Bookbinder,Etienne Brodu,David Caldwell,Anthony W. Case,Benjamin D. G. Chandran,Peter Cheimets,Jonathan Cirtain,Steven R. Cranmer,D. W. Curtis,Peter Daigneau,Greg Dalton,Brahmananda Dasgupta,David DeTomaso,M. Diaz-Aguado,Blagoje Djordjevic,Bill Donaskowski,Michael Effinger,Vladimir Florinski,N. J. Fox,Mark D. Freeman,Dennis L. Gallagher,S. Peter Gary,T. Gauron,Richard Gates,M. L. Goldstein,Leon Golub,D. Gordon,R. S. Gurnee,Giora Guth,Jasper Halekas,Ken Hatch,Jacob Heerikuisen,George C. Ho,Qiang Hu,Greg Johnson,Steven P. Jordan,Kelly E. Korreck,Davin Larson,Alan J. Lazarus,Gang Li,Roberto Livi,Michael Ludlam,Milan Maksimovic,James P. McFadden,William Marchant,B. Maruca,David J. McComas,David J. McComas,Luciana Messina,Tony Mercer,Sang Park,Andrew M. Peddie,Nikolai V. Pogorelov,Matthew J. Reinhart,John D. Richardson,M. S. Robinson,Irene Rosen,Ruth M. Skoug,Amanda Slagle,John T. Steinberg,Michael L. Stevens,Adam Szabo,E. Taylor,Chris Tiu,Paul Turin,Marco Velli,G. M. Webb,Phyllis Whittlesey,K. H. Wright,S. T. Wu,Gary P. Zank +80 more
TL;DR: The Solar Wind Electrons Alphas and Protons (SWEAP) Investigation on Solar Probe Plus is a four sensor instrument suite that provides complete measurements of the electrons and ionized helium and hydrogen that constitute the bulk of solar wind and coronal plasma.
Journal Article
Solar Wind Electrons Alphas and Protons (SWEAP) Investigation: Design of the Solar Wind and Coronal Plasma Instrument Suite for Solar Probe Plus
Justin C. Kasper,R. Abiad,Gerry Austin,Marianne Balat-Pichelin,Stuart D. Bale,Peter Berg,Henry Bergner,Matthieu Berthomier,Jay Bookbinder,Etienne Brodu,David Caldwell,Anthony W. Case,Benjamin D. G. Chandran,Peter Cheimets,Jonathan Cirtain,Steven R. Cranmer,D. W. Curtis,Peter Daigneau,Greg Dalton,Brahmananda Dasgupta,David DeTomaso,M. Diaz-Aguado,Blagoje Djordjevic,Bill Donaskowski,Michael Effinger,Vladimir Florinski,N. J. Fox,Mark D. Freeman,Dennis L. Gallagher,S. P. Gary,T. Gauron,Richard Gates,M. L. Goldstein,Leon Golub,D. Gordon,R. S. Gurnee,Giora Guth,Jasper Halekas,Ken Hatch,Jacob Heerikuisen,George C. Ho,Qiang Hu,Greg Johnson,Steven P. Jordan,Kelly E. Korreck,Davin Larson,Gang Li,Roberto Livi,Michael Ludlam,Milan Maksimovic,James P. McFadden,William Marchant,B. Maruca,David J. McComas,Luciana Messina,Tony Mercer,Sang Park,Andrew M. Peddie,Nikolai V. Pogorelov,Matthew J. Reinhart,M. S. Robinson,Irene Rosen,Ruth M. Skoug,Amanda Slagle,John T. Steinberg,Michael L. Stevens,Adam Szabo,E. Taylor,Chris Tiu,Paul Turin,Marco Velli,G. M. Webb,Phyllis Whittlesey,K. H. Wright,S. T. Wu,Gary P. Zank,John W. Belcher,Alan J. Lazarus,John D. Richardson +78 more
TL;DR: In this paper, the authors proposed a contract NNN06AA01C (Task NNN10AA08T) with the U.S. National Aeronautics and Space Administration.
Journal ArticleDOI
Induction of a colitogenic phenotype in Th1-like cells depends on interleukin-23 receptor signaling.
Mathias Pawlak,David DeTomaso,Alexandra Schnell,Gerd Meyer zu Horste,Youjin Lee,Jackson Nyman,Danielle Dionne,B. M. Regan,Vasundhara Singh,Toni Delorey,Markus A. Schramm,Chao Wang,Antonia Wallrapp,Patrick R. Burkett,Samantha J. Riesenfeld,J. Anderson,Aviv Regev,Ramnik J. Xavier,Nir Yosef,Vijay K. Kuchroo +19 more
TL;DR: This paper showed that Th1-like cells differentiated in vitro with IL-12 + IL-21 showed similar IL-23R expression to that of pathogenic Th17 cells using eGFP reporter mice.
Proceedings ArticleDOI
332 CRISPR/Cas9-based integration of a large and modular cassette into a safe harbor site to improve CAR T cell therapy efficacy and safety
Brendan Galvin,Grace Zheng,Robby Moot,Michelle Nguyen,Michelle Tan,Rene Sit,Lionel Berthoin,David DeTomaso,Sofia Kyriazopoulou Panagiotopoulou,Shan Sabri,Jun Feng,Manching Ku,Anzhi Yao,Andrea Liu,Jennifer McDevitt,Matt Drever,Stephen Santoro,Aaron Cooper,Susie Jun,W. Nicholas Haining,Tarjei S. Mikkelsen +20 more
TL;DR: In this paper , an integrated circuit T (ICT) was used to integrate transgenes by electroporation (CITE) into a safe-harbor locus for the treatment of ovarian cancer.
Journal ArticleDOI
Abstract 2830: Multiplexed shRNAs targeting FAS and PTPN2 enhance CAR T persistence and anti-tumor efficacy
John D. Gagnon,Adam J. Litterman,J.A.J. Hall,Dina M. Polyak,Stanley Zhou,Sahil Joshi,Oliver Takacsi-Nagy,Hans W. Pope,luisa silva,Brenal K. Singh,Jeffrey M. Granja,David DeTomaso,Edgar Aristil-Lepe,Michelle Tan,Brendan D. Galvin,Grace Zheng,Stephen Santoro,Aaron McGill Cooper,Natalie A. Bezman,W. Nicholas Haining +19 more
TL;DR: A library of 171 pair-wise gene knockouts using CRISPR-Cas9 led to a significant improvement in T cell effector function and proliferative capacity and in a tumor xenograft model, CAR T cells containing FAS/PTPN2 shRNA module demonstrated significantly improved tumor control.