Jackson Nyman

TL;DR: In this paper, the authors profile 4,347 single cells from six IDH1 or IDH2 mutant human oligodendrogliomas by RNA sequencing and reconstruct their developmental programs from genome-wide expression signatures.

TL;DR: Single-cell analyses provide insight into the cellular architecture of oligodendrogliomas at single-cell resolution and support the cancer stem cell model, with substantial implications for disease management.

TL;DR: In this paper, the authors profiled mouse lung-resident ILCs using single-cell RNA sequencing at steady state and after in vivo stimulation with the alarmin cytokines IL-25 and IL-33.

TL;DR: The dynamics of the effector response of CD8+ tumor‐infiltrating lymphocytes (TILs) after checkpoint blockade therapy was examined, showing a shift from naive‐like to memory‐precursor‐ and effector‐like subsets within PD‐1−CD8+ T cells in tumors.

TL;DR: This work analyzed population and single-cell RNA profiles of CD8(+) tumor-infiltrating lymphocytes (TILs) and used genetic perturbations to identify a distinct gene module for T-cell dysfunction that can be uncoupled from T cell activation, and identifies Gata-3, a zinc-finger transcription factor in the dysfunctional module, as a regulator of dysfunction.