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Institution

Marshall Space Flight Center

FacilityRedstone Arsenal, Alabama, United States
About: Marshall Space Flight Center is a(n) facility organization based out in Redstone Arsenal, Alabama, United States. It is known for research contribution in the topic(s): Space Shuttle & Gamma-ray burst. The organization has 6766 authors who have published 14591 publication(s) receiving 324474 citation(s). The organization is also known as: MSFC & George C. Marshall Space Flight Center.


Papers
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Journal ArticleDOI
B. P. Abbott1, Richard J. Abbott1, T. D. Abbott2, Fausto Acernese3  +1131 moreInstitutions (123)
TL;DR: The association of GRB 170817A, detected by Fermi-GBM 1.7 s after the coalescence, corroborates the hypothesis of a neutron star merger and provides the first direct evidence of a link between these mergers and short γ-ray bursts.
Abstract: On August 17, 2017 at 12∶41:04 UTC the Advanced LIGO and Advanced Virgo gravitational-wave detectors made their first observation of a binary neutron star inspiral. The signal, GW170817, was detected with a combined signal-to-noise ratio of 32.4 and a false-alarm-rate estimate of less than one per 8.0×10^{4} years. We infer the component masses of the binary to be between 0.86 and 2.26 M_{⊙}, in agreement with masses of known neutron stars. Restricting the component spins to the range inferred in binary neutron stars, we find the component masses to be in the range 1.17-1.60 M_{⊙}, with the total mass of the system 2.74_{-0.01}^{+0.04}M_{⊙}. The source was localized within a sky region of 28 deg^{2} (90% probability) and had a luminosity distance of 40_{-14}^{+8} Mpc, the closest and most precisely localized gravitational-wave signal yet. The association with the γ-ray burst GRB 170817A, detected by Fermi-GBM 1.7 s after the coalescence, corroborates the hypothesis of a neutron star merger and provides the first direct evidence of a link between these mergers and short γ-ray bursts. Subsequent identification of transient counterparts across the electromagnetic spectrum in the same location further supports the interpretation of this event as a neutron star merger. This unprecedented joint gravitational and electromagnetic observation provides insight into astrophysics, dense matter, gravitation, and cosmology.

5,922 citations

Journal ArticleDOI
TL;DR: The Modern-Era Retrospective Analysis for Research and Applications (MERRA) was undertaken by NASA's Global Modeling and Assimilation Office with two primary objectives: to place observations from NASA's Earth Observing System satellites into a climate context and to improve upon the hydrologic cycle represented in earlier generations of reanalyses as mentioned in this paper.
Abstract: The Modern-Era Retrospective Analysis for Research and Applications (MERRA) was undertaken by NASA’s Global Modeling and Assimilation Office with two primary objectives: to place observations from NASA’s Earth Observing System satellites into a climate context and to improve upon the hydrologic cycle represented in earlier generations of reanalyses. Focusing on the satellite era, from 1979 to the present, MERRA has achieved its goals with significant improvements in precipitation and water vapor climatology. Here, a brief overview of the system and some aspects of its performance, including quality assessment diagnostics from innovation and residual statistics, is given.By comparing MERRA with other updated reanalyses [the interim version of the next ECMWF Re-Analysis (ERA-Interim) and the Climate Forecast System Reanalysis (CFSR)], advances made in this new generation of reanalyses, as well as remaining deficiencies, are identified. Although there is little difference between the new reanalyses i...

4,201 citations

Journal ArticleDOI
16 Jul 1992-Nature
TL;DR: The three-dimensional structure of human serum albumin has been determined crystallographically to a resolution of 2.8 Å and should provide insight into future pharmacokinetic and genetically engineered therapeutic applications of serumalbumin.
Abstract: The three-dimensional structure of human serum albumin has been determined crystallographically to a resolution of 2.8 A. It comprises three homologous domains that assemble to form a heart-shaped molecule. Each domain is a product of two subdomains that possess common structural motifs. The principal regions of ligand binding to human serum albumin are located in hydrophobic cavities in subdomains IIA and IIIA, which exhibit similar chemistry. The structure explains numerous physical phenomena and should provide insight into future pharmacokinetic and genetically engineered therapeutic applications of serum albumin.

3,273 citations

Journal ArticleDOI
19 Feb 2010-Science
TL;DR: The Kepler mission was designed to determine the frequency of Earth-sized planets in and near the habitable zone of Sun-like stars, which is the region where planetary temperatures are suitable for water to exist on a planet's surface.
Abstract: The Kepler mission was designed to determine the frequency of Earth-sized planets in and near the habitable zone of Sun-like stars. The habitable zone is the region where planetary temperatures are suitable for water to exist on a planet’s surface. During the first 6 weeks of observations, Kepler monitored 156,000 stars, and five new exoplanets with sizes between 0.37 and 1.6 Jupiter radii and orbital periods from 3.2 to 4.9 days were discovered. The density of the Neptune-sized Kepler-4b is similar to that of Neptune and GJ 436b, even though the irradiation level is 800,000 times higher. Kepler-7b is one of the lowest-density planets (~0.17 gram per cubic centimeter) yet detected. Kepler-5b, -6b, and -8b confirm the existence of planets with densities lower than those predicted for gas giant planets.

3,240 citations

Book ChapterDOI
TL;DR: This chapter provides an insight of the findings of past significant papers with the current knowledge of the recently determined high resolution X-ray structure of serum albumin and suggests that AFP may have a higher affinity for some unknown ligands important for fetal development.
Abstract: Publisher Summary This chapter provides an insight of the findings of past significant papers with the current knowledge of the recently determined high resolution X-ray structure of serum albumin. The most outstanding property of albumin is its ability to bind reversibly an incredible variety of ligands. The sequences of all albumins are characterized by a unique arrangement of disulfide double loops that repeat as a series of triplets. Albumin belongs to a multigene family of proteins that includes α- fetoprotein (AFP) and vitamin D-binding protein (VDP), also known as G complement (Gc) protein. Although AFP is considered the fetal counterpart of albumin, its binding properties are distinct and it is suggested that AFP may have a higher affinity for some unknown ligands important for fetal development. Domain structure and the arrangement of the disulfides, the surface charge distribution, and the conformational flexibility of the albumin molecule are described. The nature of ligand binding, including small organics, long-chain fatty acids, and metals, to multiple sites on the albumin molecule is clearly depicted. The chapter concludes with the perceptive comments on future directions being taken to explore the structure and function of this fascinating protein.

2,847 citations


Authors

Showing all 6766 results

NameH-indexPapersCitations
John N. Wood12183359874
Chryssa Kouveliotou10967147748
Kip S. Thorne10536063475
Bradley M. Peterson10245538205
Fiona A. Harrison9985043921
Gerald Schubert9861434505
Tyson Littenberg8929761373
Eugenio Coronado8974033461
John Clarke8664625233
Stephen J. Smartt8129926161
L. A. Frank8144523617
Dale D. Kocevski7929730156
Kevin Hurley7950327990
Wei Shyy7869528562
Robert D. Preece7837325556
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
20225
2021216
2020292
2019389
2018427
2017455