P
Patrick R. Burkett
Researcher at Brigham and Women's Hospital
Publications - 42
Citations - 4962
Patrick R. Burkett is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Innate lymphoid cell & T cell. The author has an hindex of 21, co-authored 40 publications receiving 4024 citations. Previous affiliations of Patrick R. Burkett include Harvard University & University of California, San Francisco.
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Journal ArticleDOI
Diverse functions of il-2, il-15, and il-7 in lymphoid homeostasis
TL;DR: The discovery of a novel mechanism of cytokine signaling, trans-presentation, has provided further insights into the different ways these cytokines function and raises several novel cell biological and cellular implications concerning how cytokines support lymphoid homeostasis.
Journal ArticleDOI
Treg cells expressing the coinhibitory molecule TIGIT selectively inhibit proinflammatory Th1 and Th17 cell responses.
Nicole Joller,Ester Lozano,Patrick R. Burkett,Bonny Patel,Sheng Xiao,Chen Zhu,Junrong Xia,Tze Guan Tan,Esen Sefik,Vijay Yajnik,Arlene H. Sharpe,Arlene H. Sharpe,Francisco J. Quintana,Diane Mathis,Christophe Benoist,David A. Hafler,Vijay K. Kuchroo +16 more
TL;DR: TIGIT expression identifies a Treg cell subset that demonstrates selectivity for suppression of Th1 and Th17 cell but not Th2 cell responses.
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The neuropeptide NMU amplifies ILC2-driven allergic lung inflammation
Antonia Wallrapp,Samantha J. Riesenfeld,Patrick R. Burkett,Raja-Elie E. Abdulnour,Jackson Nyman,Danielle Dionne,Matan Hofree,Michael S. Cuoco,Christopher Rodman,Daneyal Farouq,Brian J. Haas,Timothy L. Tickle,John J. Trombetta,Pankaj Baral,Christoph S.N. Klose,Tanel Mahlakõiv,David Artis,Orit Rozenblatt-Rosen,Isaac M. Chiu,Bruce D. Levy,Monika S. Kowalczyk,Aviv Regev,Aviv Regev,Vijay K. Kuchroo,Vijay K. Kuchroo +24 more
TL;DR: In this paper, the authors profiled mouse lung-resident ILCs using single-cell RNA sequencing at steady state and after in vivo stimulation with the alarmin cytokines IL-25 and IL-33.
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Coordinate Expression and Trans Presentation of Interleukin (IL)-15Rα and IL-15 Supports Natural Killer Cell and Memory CD8+ T Cell Homeostasis
TL;DR: IL-15Rα defines homeostatic niches for NK and memory CD8+ T cells by controlling both the production and the presentation of IL-15 in trans to NK andCD8+ memory T cells.
Journal ArticleDOI
Induction and transcriptional regulation of the co-inhibitory gene module in T cells
Norio Chihara,Asaf Madi,Asaf Madi,Takaaki Kondo,Huiyuan Zhang,Nandini Acharya,Meromit Singer,Jackson Nyman,Nemanja D. Marjanovic,Monika S. Kowalczyk,Chao Wang,Sema Kurtulus,Travis Law,Yasaman Etminan,James Nevin,Christopher D. Buckley,Patrick R. Burkett,Jason D. Buenrostro,Orit Rozenblatt-Rosen,Ana C. Anderson,Ana C. Anderson,Aviv Regev,Aviv Regev,Vijay K. Kuchroo,Vijay K. Kuchroo +24 more
TL;DR: A module of co-inhibitory T cell receptors, driven by the cytokine IL-27, is identified in mice that is regulated by the transcription factors PRDM1 and c-MAF, and this was validated experimentally.