Antiphosphocholine antibodies found in normal mouse serum are protective against intravenous infection with type 3 streptococcus pneumoniae
David E. Briles,Moon H. Nahm,Kenneth R. Schroer,Joseph M. Davie,Phillip J. Baker,John F. Kearney,Raúl G. Barletta +6 more
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The antiphosphocholine antibody in normal mouse sera (NMS) provides protection against intravenous infection with encapsulated strain WU2 of type 3 Streptococcus pneumoniae.Abstract:
The antiphosphocholine (PC) antibody in normal mouse sera (NMS) provides protection against intravenous infection with encapsulated strain WU2 of type 3 Streptococcus pneumoniae. Mice unable to make anti-PC antibody, as a result of suppression with anti-T-15 idiotype or inheritance of the xid gene of CAB/N mice, are highly susceptible to infection with strain WU2. Mice inheriting the xid gene can be protected with NMS from immunologically normal mice or with IgM hybridoma anti-PC antibody. The protective effect of NMS can be removed with PC-containing immunoabsorbents.read more
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Marginal Zone and B1 B Cells Unite in the Early Response against T-Independent Blood-Borne Particulate Antigens
TL;DR: Splenic MZ and B1 B cells endowed with a "natural memory" provide a bridge between the very early innate and the later appearing adaptive immune response.
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Control of early viral and bacterial distribution and disease by natural antibodies.
Adrian F. Ochsenbein,Thomas Fehr,Claudia Lutz,Mark Suter,Frank Brombacher,Hans Hengartner,Rolf M. Zinkernagel +6 more
TL;DR: In antibody-free mice infected with various viruses or with Listeria monocytogenes, viral or bacterial Titers in peripheral organs were 10 to 100 times greater than in antibody-competent mice (and enhanced their susceptibility to some infections), and titers in secondary lymphoid organs were very low.
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Robert Berland,Henry H. Wortis +1 more
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Richard Malley,Philipp Henneke,Sarah C. Morse,Michael J. Cieslewicz,Marc Lipsitch,Claudette M. Thompson,Evelyn A. Kurt-Jones,James C. Paton,Michael R. Wessels,Douglas T. Golenbock +9 more
TL;DR: The interaction of pneumolysin with TLR4 is critically involved in the innate immune response to pneumococcus and is found to stimulate tumor necrosis factor-α and IL-6 release in wild-type macrophages but not in macrophage from mice with a targeted deletion of the cytoplasmic TLR-adapter molecule myeloid differentiation factor 88, suggesting the involvement of the TLRs in pneumoly sin recognition.
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References
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TL;DR: A reprint of Avery, MacLeod, and McCarty's article on the 35th anniversary of its original publication.
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Studies on the chemical nature of the substance inducing transformation of pneumococcal types
TL;DR: Evidence is presented that the chemically induced alterations in cellular structure and function are predictable, type-specific, and transmissible in series.
Journal ArticleDOI
Prevention of pneumococcal pneumonia by immunization with specific capsular polysaccharides
TL;DR: It is suggested that an over-all reduction in the incidence of carriers was responsible for the lowered rates for pneumococcal pneumonia in the non-immunized group.
Journal Article
Subclass restriction of murine anti-carbohydrate antibodies.
TL;DR: In this article, an analysis of the subclass distribution of murine antibodies directed against groups A and C streptococcal carbohydrate, alpha-(1 leads to 3) dextran and phosphocholine yields the surprising observation that these carbohydrate antigens stimulate IgG responses largely restricted to the rare IgG3 subclass.