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David E. Shaw
Researcher at D. E. Shaw Research
Publications - 326
Citations - 50142
David E. Shaw is an academic researcher from D. E. Shaw Research. The author has contributed to research in topics: Massively parallel & G protein-coupled receptor. The author has an hindex of 88, co-authored 298 publications receiving 42616 citations. Previous affiliations of David E. Shaw include Protein Sciences & Genentech.
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Method and system for the electronic negotiation and execution of equity block trades for institutional investors
TL;DR: In this paper, the authors present a system for electronic negotiation and execution of block-size trades in financial instruments on behalf of institutional investors, and in particular, a system and method for the anonymous execution of equity block trades for institutional investors.
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A dynamically coupled allosteric network underlies binding cooperativity in Src kinase
TL;DR: An allosteric network of dynamically coupled amino acids in Src kinase that connects regulatory sites to the ATP- and substrate-binding sites is identified and establishes a potential conduit by which resistance mutations to ATP-competitive kinase inhibitors can affect their activity.
Journal Article
Histidine-proline-rich glycoprotein has potent antiangiogenic activity mediated through the histidine-proline-rich domain.
Jose Juarez,Xiaojun Guan,Natalya V. Shipulina,Marian L. Plunkett,Graham Parry,David E. Shaw,Jing Chuan Zhang,Shafaat A. Rabbani,Keith R. McCrae,Andrew P. Mazar,William T. Morgan,Fernando Donate +11 more
TL;DR: The H/P domain within HPRG induces the apoptosis of activated endothelial cells leading to potent antiangiogenic effects.
Journal ArticleDOI
Atomic-level simulation of current–voltage relationships in single-file ion channels
TL;DR: Using long, all-atom simulations enabled by special-purpose hardware, K+ permeation across the KV1.2/2.1 voltage-gated potassium channel is studied, suggesting that the direct simulation of permeation at the single-ion level can provide fundamental physiological insight into ion channel function.
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Pharmacology of the Novel Antiangiogenic Peptide ATN-161 (Ac-PHSCN-NH2): Observation of a U-Shaped Dose-Response Curve in Several Preclinical Models of Angiogenesis and Tumor Growth
Fernando Donate,Graham Parry,Yuval Shaked,Harvey Hensley,Xiaojun Guan,Ivy Beck,Ziva Tel-Tsur,Marian L. Plunkett,Mari Manuia,David E. Shaw,Robert S. Kerbel,Andrew P. Mazar +11 more
TL;DR: The identification of biomarkers of angiogenesis that also exhibit this same U-shaped response should allow the translation of those biomarkers to the clinic, allowing them to be used to identify the active dose of ATN-161 in phase II studies.