D
David E. Shaw
Researcher at D. E. Shaw Research
Publications - 326
Citations - 50142
David E. Shaw is an academic researcher from D. E. Shaw Research. The author has contributed to research in topics: Massively parallel & G protein-coupled receptor. The author has an hindex of 88, co-authored 298 publications receiving 42616 citations. Previous affiliations of David E. Shaw include Protein Sciences & Genentech.
Papers
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Desmond Performance on a Cluster of Multicore Processors
Edmond Chow,C. A. Rendleman,Kevin J. Bowers,Ron O. Dror,Justin Gullingsrud,Federico D. Sacerdoti,David E. Shaw +6 more
TL;DR: This report documents the performance that Desmond achieved on new hardware in April 2008, and reveals its top simulation rate is 471 ns/day on 1024 cores of an InfiniBand cluster.
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Structural basis for backtracking by the SARS-CoV-2 replication-transcription complex.
Brandon Malone,James Chen,Qi Wang,Eliza Llewellyn,Young Joo Choi,Paul Dominic B. Olinares,Xinyun Cao,Carolina Hernández,Edward T. Eng,Brian T. Chait,David E. Shaw,David E. Shaw,Robert Landick,Seth A. Darst,Elizabeth A. Campbell +14 more
TL;DR: In this article, the RNA-dependent RNA polymerase (RdRp) in SARS-CoV-2 was shown to aid viral transcription and replication by backtracking.
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A Simple Model of Multivalent Adhesion and Its Application to Influenza Infection.
TL;DR: The model predicts that hemagglutinin inhibitors of relatively modest affinity can dramatically reduce influenza virus adhesion to host cells, suggesting that such inhibitors, if discovered, may be viable therapeutic agents against influenza.
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Peptides derived from the histidine-proline domain of the histidine-proline-rich glycoprotein bind to tropomyosin and have antiangiogenic and antitumor activities.
Fernando Donate,Jose Juarez,Xiaojun Guan,Natalya V. Shipulina,Marian L. Plunkett,Ziva Tel-Tsur,David E. Shaw,William T. Morgan,Andrew P. Mazar +8 more
TL;DR: It is demonstrated that a 16-mer peptide analogue mimics the antiangiogenic activity of intact HPRG and is also able to inhibit tumor growth, suggesting that cell surface tropomyosin may represent a novel antiangIogenic target for the treatment of cancer.
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Atomistic Description of the Folding of a Dimeric Protein
TL;DR: It is found that the isolated monomer is unstable but that, early in the folding pathway, nascent native structure is stabilized by contacts between the two monomer subunits, as in an induced-folding model.