D
David E. Shaw
Researcher at D. E. Shaw Research
Publications - 326
Citations - 50142
David E. Shaw is an academic researcher from D. E. Shaw Research. The author has contributed to research in topics: Massively parallel & G protein-coupled receptor. The author has an hindex of 88, co-authored 298 publications receiving 42616 citations. Previous affiliations of David E. Shaw include Protein Sciences & Genentech.
Papers
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Patent
Electronic mail system for displaying advertisement at local computer received from remote system while the local computer is off-line the remote system
David E. Shaw,Charles E. Ardai,Brian D. Marsh,Mark A. Moraes,Dana B. Rudolph,Jon D. Mc Auliffe +5 more
TL;DR: In this paper, the authors present a system for providing scheduled messages to a remote user in a batch oriented system, where a user creates and/or reads electronic mail locally and a message is displayed to the user on a portion of the local monitor, the message preferably changing in accordance with local display schedule and stored on a local storage device.
Journal ArticleDOI
Mechanism of Voltage Gating in Potassium Channels
Morten Ø. Jensen,Vishwanath Jogini,David W. Borhani,Abba E. Leffler,Ron O. Dror,David E. Shaw,David E. Shaw +6 more
TL;DR: A mechanistic model for the sodium/potassium/calcium voltage-gated ion channel superfamily is proposed that reconciles apparently conflicting experimental data.
Journal ArticleDOI
Activation mechanism of the β2-adrenergic receptor
Ron O. Dror,Daniel H. Arlow,Paul Maragakis,Thomas J. Mildorf,Albert C. Pan,Huafeng Xu,David W. Borhani,David E. Shaw +7 more
TL;DR: An activation mechanism for the β2-adrenergic receptor, a prototypical GPCR, is proposed based on atomic-level simulations in which an agonist-bound receptor transitions spontaneously from the active to the inactive crystallographically observed conformation.
Patent
Electronic mail system with advertising
David E. Shaw,Charles E. Ardai,Brian D. Marsh,Mark A. Moraes,Dana B. Rudolph,Jon D. Mc Auliffe +5 more
TL;DR: In this article, the authors present a system for providing scheduled messages to a remote user in a batch oriented system, where a user creates and/or reads electronic mail locally and a message is displayed to the user on a portion of the local monitor, the message preferably changing in accordance with local display schedule and stored on a local storage device.
Proceedings ArticleDOI
Anton 2: raising the bar for performance and programmability in a special-purpose molecular dynamics supercomputer
David E. Shaw,J. P. Grossman,Joseph A. Bank,Brannon Batson,J. Adam Butts,Jack C. Chao,Martin M. Deneroff,Ron O. Dror,Amos Even,Christopher H. Fenton,Anthony Forte,Joseph Gagliardo,Gennette Gill,Brian Greskamp,C. Richard Ho,Douglas J. Ierardi,Lev Iserovich,Jeffrey S. Kuskin,Richard H. Larson,Timothy Layman,Li-Siang Lee,Adam Lerer,Chester Li,Daniel Killebrew,Kenneth M. Mackenzie,Shark Yeuk-Hai Mok,Mark A. Moraes,Rolf Mueller,Lawrence J. Nociolo,Jon L. Peticolas,Terry Quan,Daniel Ramot,John K. Salmon,Daniele Paolo Scarpazza,U. Ben Schafer,Naseer Siddique,Christopher W. Snyder,Jochen Spengler,Ping Tak Peter Tang,Michael Theobald,Horia Toma,Brian Towles,Benjamin Vitale,Stanley C. Wang,Cliff Young +44 more
TL;DR: The architecture of Anton 2 is tailored for fine-grained event-driven operation, which improves performance by increasing the overlap of computation with communication, and also allows a wider range of algorithms to run efficiently, enabling many new software-based optimizations.