D
David F. Orr
Researcher at Ulster University
Publications - 28
Citations - 1007
David F. Orr is an academic researcher from Ulster University. The author has contributed to research in topics: Peptide & Antimicrobial peptides. The author has an hindex of 20, co-authored 28 publications receiving 949 citations. Previous affiliations of David F. Orr include Belfast Health and Social Care Trust & Queen's University Belfast.
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Journal ArticleDOI
Antimicrobial activity of neuropeptides against a range of micro-organisms from skin, oral, respiratory and gastrointestinal tract sites
TL;DR: These antimicrobial activities of SP, NPY, VIP and CGRP add a further dimension to the immunomodulatory roles for neuropeptides in the inflammatory and immune responses.
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Granular gland transcriptomes in stimulated amphibian skin secretions.
TL;DR: The discovery is presented that polyadenylated mRNAs encoding dermal granular gland peptides are present in defensive skin secretions, stabilized by endogenous nucleic acid-binding amphipathic peptides, which has important implications in conservation of biodiversity within this threatened vertebrate taxon.
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Novel bradykinins and their precursor cDNAs from European yellow‐bellied toad (Bombina variegata) skin
Tianbao Chen,Tianbao Chen,David F. Orr,Anthony J. Bjourson,Stephen McClean,Martin O'Rourke,David G. Hirst,Pingfan Rao,Christopher Shaw +8 more
TL;DR: Two novel bradykinin-related peptides, identified by a systematic sequencing study of peptides in the defensive skin secretion of the yellow-bellied toad, Bombina variegata, are the first amphibian skin brady Kinins to exhibit amino acid substitutions at the Pro3 position of the bradykinsin nonapeptide.
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Identification and overexpression of human neutrophil α-defensins (human neutrophil peptides 1, 2 and 3) in squamous cell carcinomas of the human tongue
Fionnuala Lundy,David F. Orr,James R Gallagher,Perry Maxwell,Christopher Shaw,Seamus S. Napier,C Gerald Cowan,Philip Lamey,J. J. Marley +8 more
TL;DR: It is shown that the defensins are abundant in neutrophils infiltrating human oral squamous cell carcinoma tissue, which may imply a role for alpha-defensins in host defence against Oral squamouscell carcinoma.
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Detection of individual human neutrophil alpha-defensins (human neutrophil peptides 1, 2 and 3) in unfractionated gingival crevicular fluid--a MALDI-MS approach.
TL;DR: The finding that the defensins were more abundant in a higher proportion of the healthy sites studied could be linked to a more intact defensin barrier in periodontal health.