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David G. Coughlin
Researcher at University of Pennsylvania
Publications - 36
Citations - 707
David G. Coughlin is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Medicine & Progressive supranuclear palsy. The author has an hindex of 10, co-authored 21 publications receiving 344 citations. Previous affiliations of David G. Coughlin include Pennsylvania Hospital & University of California, San Diego.
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Journal ArticleDOI
Lateralized ante mortem and post mortem pathology in a case of Lewy body disease with corticobasal syndrome
David G. Coughlin,H. Branch Coslett,Claire Peterson,Jeffrey S. Phillips,Corey T. McMillan,Edward A. Lee,John Q. Trojanowski,Murray Grossman,David J. Irwin +8 more
TL;DR: This case with overlapping tauopathy and synucleinopathy clinical features had in‐depth biomarker characterization and rare bilateral post‐mortem sampling showing lateralized tau and α‐synuclein pathology suggesting possible synergistic relationships.
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Selective tau seeding assays and isoform-specific antibodies define neuroanatomic distribution of progressive supranuclear palsy pathology arising in Alzheimer’s disease
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Digital Histological Study of Neocortical Grey and White Matter Tau Burden Across Tauopathies.
David G. Coughlin,Annie Hiniker,Claire Peterson,Yongya Kim,S. Arezoumandan,Lucia A. A. Giannini,Donald P. Pizzo,Daniel Weintraub,Andrew Siderowf,Irene Litvan,Robert A. Rissman,Douglas Galasko,L. A. Hansen,John Q. Trojanowski,Edward A. Lee,Murray Grossman,David J. Irwin +16 more
TL;DR: The feasibility of cross-institutional digital histology studies that generate finely grained measurements of pathology which can be used to support biomarker development and models of disease progression are demonstrated.
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Tau seeds occur before earliest Alzheimer’s changes and are prevalent across neurodegenerative diseases
M. Manca,Heidi Standke,Mikayla L. Huntley,Olivia R. Thomas,Christina D. Orrú,Andrew G. Hughson,Yongya Kim,Jing Zhang,Curtis Tatsuoka,Xiongwei Zhu,Annie OF Hiniker,David G. Coughlin,Douglas Galasko,Allison Kraus +13 more
TL;DR: In this paper , the authors used tau real-time quaking-induced conversion (RT-QuIC) assays to selectively quantitate 3R/4R tau seeds in the frontal lobe which accumulates histologically identifiable tau pathology at late disease stages of AD neuropathologic change.
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Case report: Neuronal intranuclear inclusion disease presenting with acute encephalopathy
Julia T. Bu,Dolores Torres,A. Robinson,Juan Carlos Vera,Shadi Daghighi,Anastasie Dunn-Pirio,Suzan Khoromi,Justin Nowell,Gabriel C. Léger,Joseph D. Ciacci,Vanessa Goodwill,M. Cuenca Estrella,David G. Coughlin,Yu-yan Guo,Nikdokht Farid +14 more
TL;DR: In this article , the authors presented three cases of pathologically proven adult-onset NIID, all presenting with episodes of acute encephalopathy with protracted workups and lengthy time between symptom onset and diagnosis.