L
Lucia A. A. Giannini
Researcher at University Medical Center Groningen
Publications - 26
Citations - 258
Lucia A. A. Giannini is an academic researcher from University Medical Center Groningen. The author has contributed to research in topics: Medicine & Frontotemporal dementia. The author has an hindex of 5, co-authored 7 publications receiving 119 citations. Previous affiliations of Lucia A. A. Giannini include Erasmus University Medical Center & Hospital of the University of Pennsylvania.
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Journal ArticleDOI
Clinical marker for Alzheimer disease pathology in logopenic primary progressive aphasia
Lucia A. A. Giannini,David J. Irwin,Corey T. McMillan,Sharon Ash,Katya Rascovsky,David A. Wolk,Vivianna M. Van Deerlin,Edward B. Lee,John Q. Trojanowski,Murray Grossman +9 more
TL;DR: Phonologic loop dysfunction is a central feature of AD-associated PPA and specifically correlates with temporoparietal neurodegeneration.
Journal ArticleDOI
Divergent patterns of TDP-43 and tau pathologies in primary progressive aphasia.
Lucia A. A. Giannini,Lucia A. A. Giannini,Sharon X. Xie,Corey T. McMillan,Mendy Liang,Andrew Williams,Charles Jester,Katya Rascovsky,David A. Wolk,Sharon Ash,Edward B. Lee,John Q. Trojanowski,Murray Grossman,David J. Irwin +13 more
TL;DR: To measure postmortem burden of frontotemporal lobar degeneration with TDP‐43 (FTLD‐TDP) or tau (FT LD‐Tau) proteinopathy across hemispheres in primary progressive aphasia (PPA) using digital histopathology and to identify clinicopathological correlates of these distinct proteinopathies.
Journal ArticleDOI
PRRT2-related phenotypes in patients with a 16p11.2 deletion.
Danique R.M. Vlaskamp,Petra M.C. Callenbach,Patrick Rump,Lucia A. A. Giannini,Eva H. Brilstra,Trijnie Dijkhuizen,Yvonne J. Vos,Anne-Marie F. van der Kevie-Kersemaekers,Jeroen Knijnenburg,Nicole de Leeuw,Rick van Minkelen,Claudia A. L. Ruivenkamp,Alexander P.A. Stegmann,Oebele F. Brouwer,Conny M. A. van Ravenswaaij-Arts +14 more
TL;DR: BIE, PKD and PKD/IC clearly showed incomplete penetrance in patients with 16p11.2 deletions, but were found in all and 95% of patients with a PRRT2 sequence variant in this study and a large literature cohort, respectively.
Journal ArticleDOI
Neurovascular dysfunction in GRN-associated frontotemporal dementia identified by single-nucleus RNA sequencing of human cerebral cortex
Emma Gerrits,Lucia A. A. Giannini,Nieske Brouwer,Shami Melhem,Danielle Seilhean,Isabelle Le Ber,Alwin Kamermans,Gijs Kooij,Helga E. de Vries,Erik Boddeke,Harro Seelaar,John C. van Swieten,Bart J. L. Eggen +12 more
TL;DR: In this article , single-nucleus RNA sequencing of microglia, astrocytes and the neurovasculature from frontal, temporal and occipital cortical tissue from control and FTD-GRN brains was performed.
Journal ArticleDOI
Frontotemporal lobar degeneration proteinopathies have disparate microscopic patterns of white and grey matter pathology
Lucia A. A. Giannini,Lucia A. A. Giannini,Lucia A. A. Giannini,Claire Peterson,Claire Peterson,Daniel T. Ohm,Daniel T. Ohm,Sharon X. Xie,Corey T. McMillan,Katya Raskovsky,Lauren Massimo,EunRah Suh,Vivianna M. Van Deerlin,David A. Wolk,John Q. Trojanowski,Edward B. Lee,Murray Grossman,David J. Irwin,David J. Irwin +18 more
TL;DR: In this paper, the authors performed a neuropathological study of subcortical white matter and adjacent grey matter in a large autopsy cohort (n = 92; FTLD-Tau, TDP-43 inclusions) using a validated digital image approach, and investigated the relationship between WM pathology burden and WM degeneration using luxol fast blue (LFB) myelin staining.