D
David Goyard
Researcher at University of Grenoble
Publications - 39
Citations - 730
David Goyard is an academic researcher from University of Grenoble. The author has contributed to research in topics: Medicine & Glycogen phosphorylase. The author has an hindex of 13, co-authored 31 publications receiving 525 citations. Previous affiliations of David Goyard include Claude Bernard University Lyon 1 & Université du Québec à Montréal.
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Journal ArticleDOI
C-Glycopyranosyl Arenes and Hetarenes: Synthetic Methods and Bioactivity Focused on Antidiabetic Potential
Éva Bokor,Sándor Kun,David Goyard,Marietta Tóth,Jean-Pierre Praly,Sébastien Vidal,László Somsák +6 more
TL;DR: This Review summarizes close to 500 primary publications and surveys published since 2000 about the syntheses and diverse bioactivities of C-glycopyranosyl (het)arenes displaying among others antioxidant, antiviral, antibiotic, antiadhesive, cytotoxic, and glycoenzyme inhibitory effects.
Journal ArticleDOI
Synthesis of Dodecavalent Fullerene‐Based Glycoclusters and Evaluation of Their Binding Properties towards a Bacterial Lectin
Samy Cecioni,Samy Cecioni,Vincent Oerthel,Julien Iehl,Michel Holler,David Goyard,Jean-Pierre Praly,Anne Imberty,Jean-François Nierengarten,Sébastien Vidal +9 more
TL;DR: PA-IL is a bacterial lectin from the opportunistic pathogen Pseudomonas aeruginosa and is involved in the recognition of glycoconjugates on human tissues and the glycoclusters obtained were evaluated as ligands of PA-IL and for their potential for competing with its binding to glycosylated surfaces.
Journal ArticleDOI
Glucose-derived spiro-isoxazolines are anti-hyperglycemic agents against type 2 diabetes through glycogen phosphorylase inhibition
David Goyard,Bálint Kónya,Aikaterini S. Chajistamatiou,Evangelia D. Chrysina,Jérémy Leroy,Sophie Balzarin,Michel Tournier,Didier Tousch,Pierre Petit,Cédric Duret,Patrick Maurel,Patrick Maurel,László Somsák,Tibor Docsa,Pál Gergely,Jean-Pierre Praly,Jacqueline Azay-Milhau,Sébastien Vidal +17 more
TL;DR: Twelve new d-glucopyranosylidene-spiro-isoxazolines have been prepared from O-peracylated exo-D- glucals by regio- and stereoselective 1,3-dipolar cycloaddition of nitrile oxides generated in situ by treatment of the corresponding oximes with bleach and these compounds decreased hepatic glucose production, which is known to be elevated in type 2 diabetes.
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Efficient atropodiastereoselective access to 5,5'-bis-1,2,3-triazoles: studies on 1-glucosylated 5-halogeno 1,2,3-triazoles and their 5-substituted derivatives as glycogen phosphorylase inhibitors.
David Goyard,Aikaterini S. Chajistamatiou,Anastasia I. Sotiropoulou,Evangelia D. Chrysina,Jean-Pierre Praly,Sébastien Vidal +5 more
TL;DR: One of the first efficient and highly atropodiastereoselective approaches to glucose-based bis-triazoles as single atropisomers with aR stereochemistry is presented, which suggests that 4,5-disubstituted 1-glucosyl-1,2,3-Triazoles bind weakly to the enzyme.
Journal ArticleDOI
Tailor-made Janus lectin with dual avidity assembles glycoconjugate multilayers and crosslinks protocells
João-Paulo Ribeiro,Sarah Villringer,David Goyard,Liliane Coche-Guérente,Manuela Höferlin,Olivier Renaudet,Winfried Römer,Anne Imberty +7 more
TL;DR: Janus lectin this article is a chimeric bispecific lectin with two rationally oriented and distinct recognition surfaces, which is able to bind independently to both fucosylated and sialylated glycoconjugates.