David Goyard

TL;DR: This Review summarizes close to 500 primary publications and surveys published since 2000 about the syntheses and diverse bioactivities of C-glycopyranosyl (het)arenes displaying among others antioxidant, antiviral, antibiotic, antiadhesive, cytotoxic, and glycoenzyme inhibitory effects.

TL;DR: PA-IL is a bacterial lectin from the opportunistic pathogen Pseudomonas aeruginosa and is involved in the recognition of glycoconjugates on human tissues and the glycoclusters obtained were evaluated as ligands of PA-IL and for their potential for competing with its binding to glycosylated surfaces.

TL;DR: Twelve new d-glucopyranosylidene-spiro-isoxazolines have been prepared from O-peracylated exo-D- glucals by regio- and stereoselective 1,3-dipolar cycloaddition of nitrile oxides generated in situ by treatment of the corresponding oximes with bleach and these compounds decreased hepatic glucose production, which is known to be elevated in type 2 diabetes.

TL;DR: One of the first efficient and highly atropodiastereoselective approaches to glucose-based bis-triazoles as single atropisomers with aR stereochemistry is presented, which suggests that 4,5-disubstituted 1-glucosyl-1,2,3-Triazoles bind weakly to the enzyme.

TL;DR: Janus lectin this article is a chimeric bispecific lectin with two rationally oriented and distinct recognition surfaces, which is able to bind independently to both fucosylated and sialylated glycoconjugates.