D
David I. Pak
Researcher at University of Colorado Denver
Publications - 10
Citations - 68
David I. Pak is an academic researcher from University of Colorado Denver. The author has contributed to research in topics: Pulmonary hypertension & Hypoxia (medical). The author has an hindex of 3, co-authored 8 publications receiving 29 citations. Previous affiliations of David I. Pak include University of Colorado Boulder.
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Journal ArticleDOI
An Hb-mediated circulating macrophage contributing to pulmonary vascular remodeling in sickle cell disease
Katherine Redinus,Jin Hyen Baek,Ayla Yalamanoglu,Hye Kyung H. Shin,Radu Moldova,Julie W. Harral,Delaney C. Swindle,David I. Pak,Scott K. Ferguson,Rachelle Nuss,Kathryn L. Hassell,Eva Nozik-Grayck,Andre F. Palmer,Mehdi A. Fini,Vijaya Karoor,Kurt R. Stenmark,Paul W. Buehler,David Irwin +17 more
TL;DR: The data suggest phenotypic similarities between pulmonary perivascular macrophages in the authors' rat model and human SCD with PH, indicating a potentially novel maladaptive immune response to concomitant bouts of Hb and HX exposure.
Journal ArticleDOI
Murine models of sickle cell disease and beta-thalassemia demonstrate pulmonary hypertension with distinctive features.
Paul W. Buehler,Delaney C. Swindle,David I. Pak,Mehdi A. Fini,Kathryn L. Hassell,Rachelle Nuss,Rebecca B. Wilkerson,Angelo D'Alessandro,David Irwin +8 more
TL;DR: In this article, a unique pulmonary vascular iron accumulation in lungs of sickle cell anemia pulmonary hypertension patients at autopsy was defined within the concept of iron, which is unlike findings in idiopathic or other forms of pulmonary arterial hypertension.
Journal ArticleDOI
The effect of dietary nitrate supplementation on the speed-duration relationship in mice with sickle cell disease
Scott K. Ferguson,Scott K. Ferguson,Katherine Redinius,Julie W. Harral,David I. Pak,Delaney C. Swindle,Daniel M. Hirai,Jamie R. Blackwell,Andrew M. Jones,Kurt R. Stenmark,Paul W. Buehler,David Irwin +11 more
TL;DR: The potential utility of a dietary nitrate intervention to improve functionality in SCD patients is supported and exercise tolerance, measured via CS, was significantly lower in BERK mice relative to WT, but BERk mice receiving 5 days of nitrate supplementation exhibited no difference in exercise tolerance when compared to WT.
Journal ArticleDOI
Effects of living at moderate altitude on pulmonary vascular function and exercise capacity in mice with sickle cell anaemia.
Scott K. Ferguson,Katherine Redinius,Ayla Yalamanoglu,Julie W. Harral,Jin Hyen Baek,David I. Pak,Zoe Loomis,Daniel Hassell,Paul Eigenberger,Eva Nozik-Grayck,Rachelle Nuss,Kathryn L. Hassell,Kurt R. Stenmark,Paul W. Buehler,David Irwin +14 more
TL;DR: In this paper, the authors showed that exposure to mild and moderate altitude increased rates of haemolysis and right ventricular systolic pressures in mice with SCD compared to healthy wild-type cohorts and SCD mice at sea level.
Journal ArticleDOI
Impact of cell-free hemoglobin on contracting skeletal muscle microvascular oxygen pressure dynamics.
Scott K. Ferguson,Julie W. Harral,David I. Pak,Katherine Redinius,Kurt R. Stenmark,Dominik J. Schaer,Paul W. Buehler,David Irwin +7 more
TL;DR: The unchanged PO2mv steady-state observed following Hb + Hp further indicates that vascular compartmentalization of Hb by the scavenger protein haptoglobin may improve skeletal muscle metabolic control and potentially exercise tolerance in those afflicted with hemolytic diseases.