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David J. VanderWeele
Researcher at Northwestern University
Publications - 56
Citations - 1365
David J. VanderWeele is an academic researcher from Northwestern University. The author has contributed to research in topics: Prostate cancer & Medicine. The author has an hindex of 15, co-authored 40 publications receiving 1028 citations. Previous affiliations of David J. VanderWeele include National Institutes of Health & Johns Hopkins University.
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Journal ArticleDOI
Activity of durvalumab plus olaparib in metastatic castration-resistant prostate cancer in men with and without DNA damage repair mutations
Fatima Karzai,David J. VanderWeele,Ravi A. Madan,Helen Owens,Lisa M. Cordes,Amy Hankin,Anna Couvillon,Erin Nichols,Marijo Bilusic,Michael L. Beshiri,Kathleen Kelly,Venkatesh Krishnasamy,Sunmin Lee,Min-Jung Lee,Akira Yuno,Jane B. Trepel,Maria J. Merino,Ryan Dittamore,Jennifer L. Marte,Renee N. Donahue,Jeffrey Schlom,Keith Killian,Paul S. Meltzer,Seth M. Steinberg,James L. Gulley,Jung-Min Lee,William L. Dahut +26 more
TL;DR: Durvalumab plus olaparib has acceptable toxicity, and the combination demonstrates efficacy, particularly in men with DNA damage repair (DDR) mutations treated with checkpoint inhibitors.
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Inhibition of glycolysis modulates prednisolone resistance in acute lymphoblastic leukemia cells.
Esther Hulleman,Karin M. Kazemier,Amy Holleman,David J. VanderWeele,Charles M. Rudin,Mathilde J.C. Broekhuis,William E. Evans,Rob Pieters,Monique L. den Boer +8 more
TL;DR: It is shown that prednisolone resistance is associated with increased glucose consumption and that inhibition of glycolysis sensitizes prednisOLone-resistant ALL cell lines to glucocorticoids, and that targeting glyCOlysis is a viable strategy for modulating prednisoone resistance in ALL.
Journal Article
Inhibition of glutathione synthesis reverses Bcl-2-mediated cisplatin resistance.
Charles M. Rudin,Zejia Yang,Lisa M. Schumaker,David J. VanderWeele,Kenneth Newkirk,Merrill J. Egorin,Eleanor G. Zuhowski,Kevin J. Cullen +7 more
TL;DR: The results suggest that apoptotic signaling after genotoxic exposure can be inhibited by the antioxidant activity of glutathione, which contributes to cell survival by mechanisms independent of cisplatin inactivation or inhibition of DNA adduct formation.
Journal Article
Akt up-regulation increases resistance to microtubule-directed chemotherapeutic agents through mammalian target of rapamycin
TL;DR: Activation of the Akt-mTOR signaling pathway can augment glucose utilization and promote resistance to chemotherapeutic agents that do not directly target metabolic regulation, providing insight into potentially synergistic combinations of anticancer therapies.
Journal ArticleDOI
Past, Current, and Future of Immunotherapies for Prostate Cancer.
Adeline N Boettcher,Ahmed Usman,Alicia K. Morgans,David J. VanderWeele,Jeffrey A. Sosman,Jennifer D. Wu +5 more
TL;DR: Preclinical investigations show promise with the recent description of alternative ways to circumvent the immunosuppressive nature of the prostate tumor microenvironment, including harnessing the immune stimulatory NKG2D pathway, inhibiting myeloid derived suppressor cells, and utilizing immunomodulatory oncolytic viruses.