D
David J. Wong
Researcher at Stanford University
Publications - 33
Citations - 11307
David J. Wong is an academic researcher from Stanford University. The author has contributed to research in topics: Cancer & Cellular differentiation. The author has an hindex of 24, co-authored 33 publications receiving 10422 citations. Previous affiliations of David J. Wong include Howard Hughes Medical Institute & Mount Sinai Hospital, Toronto.
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Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis
Rajnish A. Gupta,Nilay Shah,Kevin C. Wang,Jeewon Kim,Hugo M. Horlings,David J. Wong,Miao-Chih Tsai,Tiffany Hung,Pedram Argani,John L. Rinn,Yulei Wang,Pius Brzoska,Benjamin Kong,Rui-Chun Li,Robert B. West,Marc J. van de Vijver,Saraswati Sukumar,Howard Y. Chang +17 more
TL;DR: It is shown that lincRNAs in the HOX loci become systematically dysregulated during breast cancer progression, indicating that l incRNAs have active roles in modulating the cancer epigenome and may be important targets for cancer diagnosis and therapy.
Journal ArticleDOI
Extensive and coordinated transcription of noncoding RNAs within cell-cycle promoters
Tiffany Hung,Yulei Wang,Michael F. Lin,Michael F. Lin,Ashley K. Koegel,Yojiro Kotake,Yojiro Kotake,Gavin D. Grant,Hugo M. Horlings,Nilay Shah,Christopher B. Umbricht,Pei Wang,Yu Wang,Benjamin Kong,Anita Langerød,Anne Lise Børresen-Dale,Seung K. Kim,Marc J. van de Vijver,Saraswati Sukumar,Michael L. Whitfield,Manolis Kellis,Manolis Kellis,Yue Xiong,David J. Wong,Howard Y. Chang +24 more
TL;DR: In this article, an ultra-high-density array that tiles the promoters of 56 cell-cycle genes was used to interrogate 108 samples representing diverse perturbations, identifying 216 transcribed regions that encode putative lncRNAs, many with RT-PCR-validated periodic expression during the cell cycle.
Extensive and coordinated transcription of noncoding RNAs within cell-cycle promoters
Tiffany Hung,Yulei Wang,Michael F. Lin,Michael F. Lin,Ashley K. Koegel,Yojiro Kotake,Yojiro Kotake,Gavin D. Grant,Hugo M. Horlings,Nilay Shah,Christopher B. Umbricht,Pei Wang,Yu Wang,Benjamin Kong,Anita Langerød,Anne Lise Børresen-Dale,Seung K. Kim,Marc J. van de Vijver,Saraswati Sukumar,Michael L. Whitfield,Manolis Kellis,Manolis Kellis,Yue Xiong,David J. Wong,Howard Y. Chang +24 more
TL;DR: This work uses an ultrahigh-density array that tiles the promoters of 56 cell-cycle genes to interrogate 108 samples representing diverse perturbations and identifies 216 transcribed regions that encode putative lncRNAs, many with RT-PCR–validated periodic expression during the cell cycle.
Journal ArticleDOI
Module map of stem cell genes guides creation of epithelial cancer stem cells.
TL;DR: Activation of an ESC-like transcriptional program in differentiated adult cells may induce pathologic self-renewal characteristic of cancer stem cells, as revealed by a gene module map constructed.
Journal ArticleDOI
The formation and maintenance of the definitive endoderm lineage in the mouse: involvement of HNF3/forkhead proteins.
TL;DR: The discovery that the rat hepatocyte transcription factor HNF3 is similar to the Drosophila forkhead gene, which plays a critical role in gut development in the fly, led us to isolate genes containing the H NF3/forkhead (HFH) domain that are expressed in mouse endoderm development and discover a novel HFH-containing gene.