M
Miao-Chih Tsai
Researcher at Stanford University
Publications - 9
Citations - 9000
Miao-Chih Tsai is an academic researcher from Stanford University. The author has contributed to research in topics: HOTAIR & Regulation of gene expression. The author has an hindex of 7, co-authored 7 publications receiving 8210 citations. Previous affiliations of Miao-Chih Tsai include Howard Hughes Medical Institute.
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Journal ArticleDOI
Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis
Rajnish A. Gupta,Nilay Shah,Kevin C. Wang,Jeewon Kim,Hugo M. Horlings,David J. Wong,Miao-Chih Tsai,Tiffany Hung,Pedram Argani,John L. Rinn,Yulei Wang,Pius Brzoska,Benjamin Kong,Rui-Chun Li,Robert B. West,Marc J. van de Vijver,Saraswati Sukumar,Howard Y. Chang +17 more
TL;DR: It is shown that lincRNAs in the HOX loci become systematically dysregulated during breast cancer progression, indicating that l incRNAs have active roles in modulating the cancer epigenome and may be important targets for cancer diagnosis and therapy.
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Long Noncoding RNA as Modular Scaffold of Histone Modification Complexes
Miao-Chih Tsai,Ohad Manor,Yue Wan,Nima Mosammaparast,Jordon K. Wang,Fei Lan,Yang Shi,Eran Segal,Howard Y. Chang +8 more
TL;DR: The results suggest that lincRNAs may serve as scaffolds by providing binding surfaces to assemble select histone modification enzymes, thereby specifying the pattern of histone modifications on target genes.
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Long Intergenic Noncoding RNAs: New Links in Cancer Progression
TL;DR: A perspective on recent results regarding noncoding transcription in cancer progression is given, focusing on the emerging role of long intergenic nonc coding RNAs (lincRNAs), which exhibit distinct gene expression patterns in primary tumors and metastases.
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Direct Lineage Conversion of Terminally Differentiated Hepatocytes to Functional Neurons
Samuele Marro,Zhiping P. Pang,Nan Yang,Miao-Chih Tsai,Kun Qu,Howard Y. Chang,Thomas C. Südhof,Marius Wernig +7 more
TL;DR: It is demonstrated that terminally differentiated hepatocytes can be directly converted into functional iN cells, and the reprogramming factors lead to a binary lineage switch decision rather than an induction of hybrid phenotypes, butiN cells retain a small but detectable epigenetic memory of their donor cells.
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Targeted Disruption of Hotair Leads to Homeotic Transformation and Gene Derepression
Lingjie Li,Bo Liu,Orly L. Wapinski,Miao-Chih Tsai,Kun Qu,Jiajing Zhang,Jeffrey C. Carlson,Meihong Lin,Fengqin Fang,Rajnish A. Gupta,Jill A. Helms,Howard Y. Chang +11 more
TL;DR: It is shown that targeted deletion of mouse Hotair lncRNA leads to derepression of hundreds of genes, resulting in homeotic transformation of the spine and malformation of metacarpal-carpal bones.