David Leibowitz

TL;DR: The results indicate that unique restriction fragments are presented in normal DNA and absent in Lepore DNA, and allow preliminary ordering of these fragments on a restriction enzyme map.

TL;DR: Restriction mapping of the chromosome 22 translocation breakpoints performed for 26 patients showed that the breakpoints of eight of the nine patients in blast crisis were in the 3′ portion of the bcr, whereas the break points in the 17 patients in the chronic phase were clustered in the 5′ portionof the bCr, suggesting a strong correlation between a 3′ bcr breakpoint and blast crisis in CML.

TL;DR: Larger thrombus size and flow velocity at the anastomotic site may guide prognosis and clinical management and greater acceleration of flow through a narrowed pulmonary vein correlated with poor clinical outcome.

TL;DR: The location of the deletions suggests that some mechanism maintains the chromosomal breakpoint on the Philadelphia chromosome within a limited region, and complicate the interpretation of Southern blots as a means of detecting the translocation.

TL;DR: Human cellular DNA fragments from cells of normal subjects and patients with thalassemia obtained by restriction enzyme digestion were analyzed for their globin gene content and results are consistent with deletion of specific restriction human DNA fragments in subjects with these disorders and a greater deletion of beta-like gene sequences in Subjects with hereditary persistence of fetal hemoglobin.