D
David M. Ojcius
Researcher at University of the Pacific (United States)
Publications - 82
Citations - 3285
David M. Ojcius is an academic researcher from University of the Pacific (United States). The author has contributed to research in topics: Apoptosis & Antigen. The author has an hindex of 24, co-authored 82 publications receiving 2807 citations. Previous affiliations of David M. Ojcius include University of Paris & Chang Gung University.
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Journal ArticleDOI
Measures for diagnosing and treating infections by a novel coronavirus responsible for a pneumonia outbreak originating in Wuhan, China.
TL;DR: Advances in research and development of fast diagnosis methods, as well as potential prophylactics and therapeutics to prevent or treat 2019-nCoV infection are focused on.
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Functional gene transfer from intracellular bacteria to mammalian cells
Catherine Grillot-Courvalin,Sylvie Goussard,Frarnçois Huetz,David M. Ojcius,Patrice Courvalin +4 more
TL;DR: Evidence of direct transfer of functional DNA from bacteria to mammalian cells is provided and transfer efficiency was enhanced in some cells by coexpression of the gene for listeriolysin from Listeria monocytogenes.
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Interleukin-10 inhibits tumor metastasis through an NK cell-dependent mechanism.
Li-Mou Zheng,David M. Ojcius,F. Garaud,C. Roth,E. Maxwell,Z. Li,H. Rong,J. Chen,X. Y. Wang,J. J. Catino,I. King +10 more
TL;DR: It is reported that injected IL-10 protein is an efficient inhibitor of tumor metastasis in experimental and spontaneous metastasis models in vivo at doses that do not have toxic effects on normal or cancer cells.
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The intrinsic pKa values for phosphatidylserine and phosphatidylethanolamine in phosphatidylcholine host bilayers.
TL;DR: Potentiometric titrations and surface potential measurements have been used to determine the intrinsic pKa values of both the carboxyl and amino groups of phosphatidylserine (PS) and the amino group of PE in PE-PC vesicles, independent of the aqueous phase ionic strength and of the effect of the liposome's surface potential.
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P2Z/P2X7 receptor-dependent apoptosis of dendritic cells.
Robson Coutinho-Silva,Pedro M. Persechini,Rodrigo C. Bisaggio,Jean-Luc Perfettini,Ana Cristina Torres De Sa Neto,Jean M. Kanellopoulos,Iris Motta-Ly,Alice Dautry-Varsat,David M. Ojcius +8 more
TL;DR: Macrophages and thymocytes express P2Z/P2X7nucleotide receptors that bind extracellular ATP, and brief treatment with ATP led to an increase in the intracellular calcium concentration and permeabilization of the plasma membrane to Lucifer yellow, which diffused throughout the dendritic cell cytosol.