D
David M. Suter
Researcher at École Polytechnique Fédérale de Lausanne
Publications - 51
Citations - 3482
David M. Suter is an academic researcher from École Polytechnique Fédérale de Lausanne. The author has contributed to research in topics: Transcription factor & Embryonic stem cell. The author has an hindex of 24, co-authored 47 publications receiving 2907 citations. Previous affiliations of David M. Suter include École Normale Supérieure & University of Oxford.
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Journal ArticleDOI
Mammalian genes are transcribed with widely different bursting kinetics
David M. Suter,Nacho Molina,David Gatfield,David Gatfield,Kim Schneider,Ueli Schibler,Felix Naef +6 more
TL;DR: This work established various gene trap cell lines and transgenic cell lines expressing a short-lived luciferase protein from an unstable mRNA, and recorded bioluminescence in real time in single cells, demonstrating that bursting kinetics are highly gene-specific.
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Single Molecule Imaging of Transcription Factor Binding to DNA in Live Mammalian Cells
J. Christof M. Gebhardt,David M. Suter,Rahul Roy,Rahul Roy,Ziqing W. Zhao,Alec R. Chapman,Srinjan Basu,Srinjan Basu,Srinjan Basu,Tom Maniatis,X. Sunney Xie +10 more
TL;DR: Reflected light-sheet microscopy (RLSM), a fluorescence microscopy method allowing selective plane illumination throughout the nuclei of living mammalian cells, is developed and single-molecule measurements and statistical analysis revealed dynamic properties of transcription factors.
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Human Serum IgM Glycosylation IDENTIFICATION OF GLYCOFORMS THAT CAN BIND TO MANNAN-BINDING LECTIN
James N. Arnold,Mark R. Wormald,David M. Suter,Catherine M. Radcliffe,David Harvey,Raymond A. Dwek,Pauline M. Rudd,Robert B. Sim +7 more
TL;DR: In this paper, the glycosylation of human polyclonal IgM from serum has been analyzed, and it was found that IgM has two distinct faces, only one of which can bind to antigen, as the J chain projects from the non-antigen-binding face.
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Stimulus-induced modulation of transcriptional bursting in a single mammalian gene
TL;DR: Combining single-cell time-lapse luminescence imaging with stochastic modeling of the time traces quantified the transcriptional responses of the endogenous connective tissue growth factor gene to different physiological stimuli: serum and TGF-β1.
Journal ArticleDOI
A role for mitotic bookmarking of SOX2 in pluripotency and differentiation
Cédric Deluz,Elias T. Friman,Daniel Strebinger,Alexander Benke,Mahé Raccaud,A. Callegari,Marion Leleu,Suliana Manley,David M. Suter +8 more
TL;DR: This study demonstrates the mitotic bookmarking property of SOX2 and reveals its functional importance in pluripotency maintenance and ES cell differentiation and investigated the function ofSOX2 mitoticBooking in cell fate decisions.