D
David M. Weiner
Researcher at ACADIA Pharmaceuticals Inc.
Publications - 54
Citations - 3381
David M. Weiner is an academic researcher from ACADIA Pharmaceuticals Inc.. The author has contributed to research in topics: Receptor & 5-HT5A receptor. The author has an hindex of 26, co-authored 45 publications receiving 3230 citations. Previous affiliations of David M. Weiner include Laboratory of Molecular Biology & University of California, San Diego.
Papers
More filters
Book ChapterDOI
The Dopamine D1 Receptors
Hyman B. Niznik,Roger K. Sunahara,Hubert H.M. Van Tol,Philip Seeman,David M. Weiner,Tom M. Stormann,Mark R. Brann,O'dowd Brian F +7 more
TL;DR: Dopaminergic receptors are members of a large gene family of hormone/neurotransmitter receptors that exert their biological actions via signal transduction pathways that involve guanine nucleotide-binding proteins.
Journal ArticleDOI
The human angiotensin AT1 receptor supports G protein-independent extracellular signal-regulated kinase 1/2 activation and cellular proliferation
Jakob Lerche Hansen,Jakob Lerche Hansen,Jakob Lerche Hansen,Mark Aplin,Mark Aplin,Jonas Tind Hansen,Jonas Tind Hansen,Jonas Tind Hansen,Gitte Lund Christensen,Gitte Lund Christensen,Gitte Lund Christensen,Marie Mi Bonde,Marie Mi Bonde,Mikael Schneider,Mikael Schneider,Stig Haunsø,Hans H. Schiffer,Ethan S. Burstein,David M. Weiner,Søren P. Sheikh,Søren P. Sheikh +20 more
TL;DR: It is shown that the human angiotensin AT(1) receptor signals directly through G protein-independent pathways and supports NIH3T3 cellular proliferation, which has clear pharmacological implications for development of drugs with pathway-specific actions and defined biological outcomes.
Journal ArticleDOI
Pharmacology of polymorphic variants of the human 5-HT1A receptor.
Andria L. Del Tredici,Hans H. Schiffer,Ethan S. Burstein,Jelveh Lameh,Nina Mohell,Uli Hacksell,Mark R. Brann,Mark R. Brann,David M. Weiner,David M. Weiner +9 more
TL;DR: Data suggest a previously unappreciated role for transmembrane 1 in mediating 5-HT response at the5-HT1A receptor and individuals that potentially harbor the A50V polymorphism might display aberrant affective behaviors and altered responses to drugs targeting the 5- HT1A receptors.
Journal ArticleDOI
Loss-of-function polymorphic variants of the human angiotensin II type 1 receptor.
TL;DR: Functional analysis using the cell-based assay receptor selection and amplification technology revealed that polymorphic variation in the human AT1 receptor induces loss of functional phenotypes, which may constitute the molecular basis of variability of AT1 receptors-mediated physiological responses.
Patent
Use of 4-amino-piperidines for treating sleep disorders
TL;DR: Inverse agonists and antagonists of serotonin receptors are disclosed for use in treating sleep disorders such as insomnia, and specifically sleep maintenance insomnia as mentioned in this paper, which increase slow wave sleep, decrease the number of awakenings after sleep onset, and decrease the time awake after sleeping onset.