J
Jakob Lerche Hansen
Researcher at Novo Nordisk
Publications - 54
Citations - 2304
Jakob Lerche Hansen is an academic researcher from Novo Nordisk. The author has contributed to research in topics: Angiotensin II & Receptor. The author has an hindex of 24, co-authored 54 publications receiving 2126 citations. Previous affiliations of Jakob Lerche Hansen include ACADIA Pharmaceuticals Inc. & University of Copenhagen.
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Journal ArticleDOI
Deciphering biased-agonism complexity reveals a new active AT1 receptor entity
Aude Saulière,Morgane Bellot,Hervé Paris,Colette Denis,Frédéric Finana,Jonas Tind Hansen,Marie-Françoise Altié,Marie-Hélène Seguelas,Atul Pathak,Jakob Lerche Hansen,Jean-Michel Senard,Céline Galés +11 more
TL;DR: New, highly sensitive and direct bioluminescence resonance energy transfer-based G protein activation probes specific for all G protein isoforms are developed and used to evaluate the G protein-coupling activity of angiotensin II, a biased agonist that may stabilize and create a new distinct active pharmacological receptor entity.
Journal ArticleDOI
S100A4: a common mediator of epithelial-mesenchymal transition, fibrosis and regeneration in diseases?
TL;DR: The possible roles of S100A4 in non-cancer diseases are explored and underlying biological mechanisms including a change in cellular phenotype towards less tightly adherent cells and activation of fibrotic processes that may explain this protein's involvement in multiple pathologies are described.
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Quantitative Phosphoproteomics Dissection of Seven-transmembrane Receptor Signaling Using Full and Biased Agonists
Gitte Lund Christensen,Gitte Lund Christensen,Gitte Lund Christensen,Christian D. Kelstrup,Christina Lyngsø,Christina Lyngsø,Uzma Sarwar,Rikke Bøgebo,Søren P. Sheikh,Steen Gammeltoft,Jesper V. Olsen,Jakob Lerche Hansen,Jakob Lerche Hansen +12 more
TL;DR: This study provides substantial novel insight into angiotensin II signal transduction and is the first study dissecting the differences between a full agonist and a biased agonist from a 7TMR on a systems-wide scale.
Journal ArticleDOI
S100A4 is upregulated in injured myocardium and promotes growth and survival of cardiac myocytes.
Mikael Schneider,Sawa Kostin,Claes C Strøm,Mark Aplin,Stig Lyngbæk,Juliane Theilade,Mariam Grigorian,Claus B. Andersen,Eugene Lukanidin,Jakob Lerche Hansen,Søren P. Sheikh +10 more
TL;DR: Findings suggest that S100A4 can act as a novel cardiac growth and survival factor and may have regenerative effects in injured myocardium.
Journal ArticleDOI
Extracellular calcium sensing in rat aortic vascular smooth muscle cells.
Sanela Smajilovic,Jakob Lerche Hansen,Jakob Lerche Hansen,Tue E H Christoffersen,Tue E H Christoffersen,Ewa Lewin,Søren P. Sheikh,Søren P. Sheikh,Ernest F. Terwilliger,Edward M. Brown,Stig Haunsø,Stig Haunsø,Jacob Tfelt-Hansen,Jacob Tfelt-Hansen +13 more
TL;DR: It is shown that Ca(2+)(o) stimulates proliferation of the cells and an additional calcium-sensing mechanism may exist and may be of importance with regard to atherosclerosis, an inflammatory disease characterized by abnormal proliferation of VSMCs and high local levels of calcium.