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David Martín
Researcher at Pompeu Fabra University
Publications - 56
Citations - 2648
David Martín is an academic researcher from Pompeu Fabra University. The author has contributed to research in topics: Ecdysone & Metamorphosis. The author has an hindex of 23, co-authored 56 publications receiving 2239 citations. Previous affiliations of David Martín include Michigan State University & Spanish National Research Council.
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Journal ArticleDOI
The mevalonate pathway and the synthesis of juvenile hormone in insects.
TL;DR: The data suggest that the mevalonate pathway in insects can best be interpreted in terms of coordinated regulation, in which regulators act in parallel to a number of enzymes, as occurs in the cholesterol-driven pathway in vertebrates.
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Molecular biology of mosquito vitellogenesis: from basic studies to genetic engineering of antipathogen immunity.
Alexander S. Raikhel,Vladimir A. Kokoza,Jinsong Zhu,David Martín,Sheng-Fu Wang,Chao Li,Guoqiang Sun,Abdoulaziz Ahmed,Neal T. Dittmer,Geoff Attardo +9 more
TL;DR: This study showed that several transcription factors involved in controlling the Vg gene expression, are themselves targets of the blood meal-mediated regulatory cascade, thus greatly amplifying the effect of this cascade on the V g gene.
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Transcriptional regulation of the mosquito vitellogenin gene via a blood meal-triggered cascade.
Vladimir A. Kokoza,David Martín,Michael J. Mienaltowski,Abdouelaziz Ahmed,Christina M Morton,Alexander S. Raikhel +5 more
TL;DR: The present work elucidates the molecular basis of blood meal-dependent expression of this mosquito gene, laying the foundation for mosquito-specific expression cassettes with predictable stage and tissue specificity.
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The vitellogenin gene of the mosquito Aedes aegypti is a direct target of ecdysteroid receptor.
TL;DR: It is demonstrated that the Vg 5'-regulatory region contains a functional ecdysteroid-responsive element (VgEcRE1) that is necessary to confer responsiveness to 20E, which is likely that the EcR-USP receptor acts synergistically with other transcription factors to bring about the high level of Vg gene expression.
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Transcription factor E93 specifies adult metamorphosis in hemimetabolous and holometabolous insects.
TL;DR: It is reported that a single factor, E93, controls juvenile-to-adult transition in hemimetabolous and holometabolous insects, thus acting as the universal adult specifier in winged insects.