Journal ArticleDOI
The mevalonate pathway and the synthesis of juvenile hormone in insects.
TLDR
The data suggest that the mevalonate pathway in insects can best be interpreted in terms of coordinated regulation, in which regulators act in parallel to a number of enzymes, as occurs in the cholesterol-driven pathway in vertebrates.Abstract:
The mevalonate pathway in insects has two important peculiarities, the absence of the sterol branch and the synthesis of juvenile hormone (JH), that may have influenced the mechanisms of regulation. The data available on these mechanisms indicate that cholesterol does not play a regulatory role and that JH modulates transcript levels of a number of genes of the mevalonate pathway or can influence the translatability and/or stability of the transcripts themselves. These data suggest that the mevalonate pathway in insects can best be interpreted in terms of coordinated regulation, in which regulators act in parallel to a number of enzymes, as occurs in the cholesterol-driven pathway in vertebrates.read more
Citations
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Journal ArticleDOI
The monarch butterfly genome yields insights into long-distance migration
TL;DR: The monarch genome reveals a vertebrate-like opsin whose existence in insects is widespread; a full repertoire of molecular components for the monarch circadian clockwork; all members of the juvenile hormone biosynthetic pathway whose regulation shows unexpected sexual dimorphism; and a variant of the sodium/potassium pump that underlies a valuable chemical defense mechanism.
Journal ArticleDOI
Drosophila neuropeptides in regulation of physiology and behavior
Dick R. Nässel,Åsa M. E. Winther +1 more
TL;DR: An overview of the physiological and behavioral roles of peptide signaling in Drosophila include regulation of development, growth, feeding, metabolism, reproduction, homeostasis, and longevity, as well as neuromodulation in learning and memory, olfaction and locomotor control.
Journal ArticleDOI
Surge in insect resistance to transgenic crops and prospects for sustainability.
Bruce E. Tabashnik,Yves Carrière +1 more
TL;DR: Global monitoring data reported during the first two decades of transgenic crops was analyzed, with each case representing the responses of one pest species in one country to one insecticidal protein from Bacillus thuringiensis (Bt).
Journal ArticleDOI
Molecular traces of alternative social organization in a termite genome
Nicolas Terrapon,Nicolas Terrapon,Cai Li,Hugh M. Robertson,Lu Ji,Xuehong Meng,Warren Booth,Warren Booth,Zhensheng Chen,Christopher P. Childers,Karl M. Glastad,Kaustubh Gokhale,Johannes Gowin,Johannes Gowin,Wulfila Gronenberg,Russell A. Hermansen,Haofu Hu,Brendan G. Hunt,Ann Kathrin Huylmans,Ann Kathrin Huylmans,Sayed M.S. Khalil,Robert D. Mitchell,Monica Munoz-Torres,Julie A. Mustard,Hailin Pan,Justin T. Reese,Michael E. Scharf,Fengming Sun,Heiko Vogel,Jin Xiao,Wei Yang,Zhikai Yang,Zuoquan Yang,Jiajian Zhou,Jiwei Zhu,Colin S. Brent,Christine G. Elsik,Michael A. D. Goodisman,David A. Liberles,R. Michael Roe,Edward L. Vargo,Andreas Vilcinskas,Jun Wang,Erich Bornberg-Bauer,Judith Korb,Guojie Zhang,Juergen Liebig +46 more
TL;DR: The genome and stage-specific transcriptomes of the dampwood termite Zootermopsis nevadensis (Blattodea) are sequence and similarities in the number and expression of genes related to caste determination mechanisms support a hypothesized epigenetic regulation of caste differentiation.
Journal ArticleDOI
Cholesterol manipulation by West Nile virus perturbs the cellular immune response.
TL;DR: It is proposed that, by manipulating cellular cholesterol, WNV utilizes the cellular response to cholesterol deficiency and dependence of antiviral signaling pathways on cholesterol-rich microdomains to facilitate viral replication and survival.
References
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Journal ArticleDOI
Regulation of the mevalonate pathway.
TL;DR: The mevalonate pathway produces isoprenoids that are vital for diverse cellular functions, ranging from cholesterol synthesis to growth control, and could be useful in treating certain forms of cancer as well as heart disease.
Journal ArticleDOI
Domain structure of mitochondrial and chloroplast targeting peptides.
TL;DR: Representative samples of mitochondrial and chloroplast targeting peptides have been analyzed in terms of amino acid composition, positional amino acid preferences and amphiphilic character and no highly conserved 'homology blocks' are found in either class of topogenic sequence.
Journal ArticleDOI
Insect P450 enzymes.
TL;DR: Polymorphisms in induction or constitutive expression allow insects to scan their P450 gene repertoire for the appropriate response to chemical insults, and these evolutionary pressures in turn maintain P450 diversity.
Journal ArticleDOI
Insect pheromones—an overview of biosynthesis and endocrine regulation
TL;DR: A molecular level understanding of the regulation of insect pheromone biosynthesis is in its infancy, and in the male California fivespined ips, Ips paraconfusus (Coleoptera: Scolytidae), JH III acts at the transcriptional level by increasing the abundance of mRNA for 3-hydroxy-3-methylglutaryl-CoA reductase, a key enzyme in de novo isoprenoid aggregation pheromsynthesis.
Journal ArticleDOI
Sterol regulatory element-binding proteins: transcriptional activators of lipid synthesis.
TL;DR: The unique regulation and activation properties of each SREBP isoform facilitates the co-ordinate regulation of all essential lipid building blocks required for cell membranes as well as for very-low-density lipoprotein formation in hepatocytes.
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