D
David Matallanas
Researcher at University College Dublin
Publications - 77
Citations - 3658
David Matallanas is an academic researcher from University College Dublin. The author has contributed to research in topics: Hippo signaling pathway & MAPK/ERK pathway. The author has an hindex of 30, co-authored 72 publications receiving 3105 citations. Previous affiliations of David Matallanas include Spanish National Research Council & University of Glasgow.
Papers
More filters
Journal ArticleDOI
RASSF1A elicits apoptosis through an MST2 pathway directing proapoptotic transcription by the p73 tumor suppressor protein.
David Matallanas,David Romano,Karen Yee,Katrin Meissl,Lucia Kucerova,Daniela Piazzolla,Manuela Baccarini,J. Keith Vass,Walter Kolch,Eric O'Neill +9 more
TL;DR: In this paper, an MST2-dependent effector pathway for RASSF1A proapoptotic signaling was proposed, where the Raf1 proto-oncogene binds to MST 2 to prevent its activation.
RASSF1A elicits apoptosis through an MST2 pathway directing proapoptotic transcription by the p73 tumor suppressor protein.
David Matallanas,David Romano,Karen Yee,Katrin Meissl,Lucia Kucerova,Daniela Piazzolla,Manuela Baccarini,J. Keith Vass,Walter Kolch,Eric O'Neill +9 more
TL;DR: It is shown that key steps in RASSF1A-induced apoptosis are the disruption of the inhibitory Raf1-MST2 complex by RASSf1A and the concomitant enhancement of MST2 interaction with its substrate, LATS1.
Journal ArticleDOI
Raf Family Kinases: Old Dogs Have Learned New Tricks
David Matallanas,Marc R. Birtwistle,David Romano,Armin Zebisch,Jens Rauch,Alex von Kriegsheim,Walter Kolch +6 more
TL;DR: The regulation of Raf proteins and their role in cancer are discussed, with special focus on the interacting proteins that modulate Raf signaling, and new kinase-independent roles for Raf proteins have emerged.
Journal ArticleDOI
Dnmt3a and Dnmt3b Associate with Enhancers to Regulate Human Epidermal Stem Cell Homeostasis
Lorenzo Rinaldi,Debayan Datta,Judit Serrat,Lluis Morey,Guiomar Solanas,Alexandra Avgustinova,Enrique Blanco,José Ignacio Pons,David Matallanas,Alex von Kriegsheim,Luciano Di Croce,Salvador Aznar Benitah +11 more
TL;DR: It is shown that in human epidermal stem cells, the two proteins bind in a histone H3K36me3-dependent manner to the most active enhancers and are required to produce their associated enhancer RNAs.
Journal ArticleDOI
Protein interaction switches coordinate Raf-1 and MST2/Hippo signalling.
David Romano,Lan K. Nguyen,David Matallanas,Melinda Halasz,Carolanne Doherty,Boris N. Kholodenko,Walter Kolch +6 more
TL;DR: It is shown that competing protein interactions can cause steep signalling switches through phosphorylation-induced changes in binding affinities, which provides a versatile regulatory mechanism for signal distribution through the dynamic integration of graded signals into switch-like responses.