M
Manuela Baccarini
Researcher at Max F. Perutz Laboratories
Publications - 90
Citations - 7483
Manuela Baccarini is an academic researcher from Max F. Perutz Laboratories. The author has contributed to research in topics: MAPK/ERK pathway & Kinase. The author has an hindex of 45, co-authored 85 publications receiving 6839 citations. Previous affiliations of Manuela Baccarini include Albert Einstein College of Medicine & Hannover Medical School.
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Journal ArticleDOI
Central role for type I interferons and Tyk2 in lipopolysaccharide-induced endotoxin shock.
Marina Karaghiosoff,Ralf Steinborn,Pavel Kovarik,Gernot Kriegshäuser,Manuela Baccarini,Birgit Donabauer,Ursula Reichart,Thomas Kolbe,Christian Bogdan,Tomas Leanderson,David E. Levy,Thomas Decker,Mathias Müller +12 more
TL;DR: It is reported that mice devoid of the JAK protein tyrosine kinase family member, Tyk2, were resistant to shock induced by high doses of LPS, and IFN-β–null but not STAT1-null mice were also resistant to high dose LPS treatment, suggesting thatTyk2 and IFn-β are essential effectors in LPS induced lethality.
Journal ArticleDOI
RASSF1A elicits apoptosis through an MST2 pathway directing proapoptotic transcription by the p73 tumor suppressor protein.
David Matallanas,David Romano,Karen Yee,Katrin Meissl,Lucia Kucerova,Daniela Piazzolla,Manuela Baccarini,J. Keith Vass,Walter Kolch,Eric O'Neill +9 more
TL;DR: In this paper, an MST2-dependent effector pathway for RASSF1A proapoptotic signaling was proposed, where the Raf1 proto-oncogene binds to MST 2 to prevent its activation.
RASSF1A elicits apoptosis through an MST2 pathway directing proapoptotic transcription by the p73 tumor suppressor protein.
David Matallanas,David Romano,Karen Yee,Katrin Meissl,Lucia Kucerova,Daniela Piazzolla,Manuela Baccarini,J. Keith Vass,Walter Kolch,Eric O'Neill +9 more
TL;DR: It is shown that key steps in RASSF1A-induced apoptosis are the disruption of the inhibitory Raf1-MST2 complex by RASSf1A and the concomitant enhancement of MST2 interaction with its substrate, LATS1.
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Embryonic lethality and fetal liver apoptosis in mice lacking the c‐raf‐1 gene
Mario Mikula,Martin Schreiber,Zvenislava Husak,Lucia Kucerova,Jochen Rüth,Rotraud Wieser,Kurt Zatloukal,Hartmut Beug,Erwin F. Wagner,Manuela Baccarini +9 more
TL;DR: It is reported that c‐raf‐1−/− embryos are growth retarded and die at midgestation with anomalies in the placenta and in the fetal liver, and that effectors distinct from the MEK/ERK cascade must mediate the anti‐apoptotic function of Raf‐1.
Journal ArticleDOI
Selective Requirement of PI3K/PDK1 Signaling for Kras Oncogene-Driven Pancreatic Cell Plasticity and Cancer
Stefan Eser,Nina Reiff,Marlena Messer,Barbara Seidler,Kathleen Gottschalk,Melanie Dobler,Maren Hieber,Andreas Arbeiter,Sabine Klein,Bo Kong,Christoph W. Michalski,Anna Melissa Schlitter,Irene Esposito,Irene Esposito,Alexander Kind,Lena Rad,Angelika Schnieke,Manuela Baccarini,Dario R. Alessi,Roland Rad,Roland Rad,Roland Rad,Roland M. Schmid,Roland M. Schmid,Guenter Schneider,Dieter Saur,Dieter Saur +26 more
TL;DR: In vivo genetic studies together with pharmacologic treatment studies in models of human ADM and PDAC demonstrate tissue-specific differences of oncogenic Kras signaling and define PI3K/PDK1 as a suitable target for therapeutic intervention specifically in PDAC.