D
David Neary
Researcher at Salford Royal NHS Foundation Trust
Publications - 220
Citations - 33304
David Neary is an academic researcher from Salford Royal NHS Foundation Trust. The author has contributed to research in topics: Frontotemporal dementia & Dementia. The author has an hindex of 78, co-authored 206 publications receiving 31481 citations. Previous affiliations of David Neary include University of Salford & Manchester Academic Health Science Centre.
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Journal ArticleDOI
TDP-43 protein in plasma may index TDP-43 brain pathology in Alzheimer's disease and frontotemporal lobar degeneration.
Penelope G. Foulds,Erica McAuley,Linda Gibbons,Yvonne S Davidson,Stuart Pickering-Brown,David Neary,Julie S. Snowden,David Allsop,David M. A. Mann +8 more
TL;DR: Using ELISA, ELISA detected elevated levels of TDP-43 protein in plasma of 46% patients with FTLD with clinical frontotemporal dementia (FTD) and 22% Patients with AD, compared to 8% of control subjects.
Journal ArticleDOI
TDP-43 pathological changes in early onset familial and sporadic Alzheimer’s disease, late onset Alzheimer’s disease and Down’s Syndrome: association with age, hippocampal sclerosis and clinical phenotype
Yvonne S Davidson,Samantha Raby,Penelope G. Foulds,Andrew C Robinson,Jennifer C. Thompson,Jennifer C. Thompson,Stephen Sikkink,Imran H. Yusuf,Hanan Amin,Daniel DuPlessis,Claire Troakes,Safa Al-Sarraj,Carolyn Sloan,Margaret M. Esiri,Vee P. Prasher,David Allsop,David Neary,Stuart Pickering-Brown,Julie S. Snowden,David M. A. Mann +19 more
TL;DR: The presence of TDP-43-ir changes in AD and DS may be a secondary phenomenon, relating more to ageing than to AD itself, Nevertheless, a challenge to such an interpretation comes from the finding in AD of a strong relationship between T DP-43 pathology and cognitive phenotype.
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Metabolic processes in Alzheimer's disease: adenine nucleotide content and production of 14CO2 from [U-14C]glucose in vitro in human neocortex.
TL;DR: The content of adenine nucleotides was significantly less than control values in the tissue from patients with Alzheimer's disease after in vitro incubations but the adenylate energy charge was unchanged, indicating that normal energy metabolism was not grossly impaired in these preparations.
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Longitudinal evaluation of cognitive disorder in Huntington's disease.
TL;DR: The study investigated longitudinal change in cognitive function in patients with Huntington's disease using a range of neuropsychological tests, which tap mental manipulative abilities, memory, and frontal executive skills, finding tasks sensitive to the progression of HD and hence most suitable for the evaluation of therapies.
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Diagnostic patterns of regional atrophy on MRI and regional cerebral blood flow change on SPECT in young onset patients with Alzheimer's disease, frontotemporal dementia and vascular dementia
Anoop Varma,W. Adams,Jim Lloyd,K. J. Carson,Julie S. Snowden,H. J. Testa,Alan Jackson,David Neary +7 more
TL;DR: The clinical diagnostic value of magnetic resonance imaging and single photon emission computed tomography (SPECT) in the differentiation of one form of dementia from another from amongst a group of AD, FTD and VaD was examined.