David Nsekpong

TL;DR: In a cluster-randomized trial conducted in Gambian villages, it is found that vaccination of children with pneumococcal conjugate vaccines reduced vaccine-type pneumitiscal carriage even among nonvaccinated older children and adults.

TL;DR: Based on the coverage of serotypes in this study, PCV-13 is the obvious choice to reduce disease burden and prevalence of drug resistant pneumococci, however, its use will require careful monitoring.

TL;DR: For over a decade, isolates of ST618 have been the dominant lineage among serotype 1 carriage and disease isolates circulating in the Gambia and shows similar epidemiological features to those of the meningococcus in the African meningitis belt being able to cause outbreaks of disease.

TL;DR: The differences in antibody responses and pneumococcal carriage between the groups diminished following booster with PPV, implying that administration of one or two doses of PCV7, with a booster dose of PPV might lower the cost of protection against IPD in young children in resource poor countries.

TL;DR: PCV-7 significantly reduced carriage of VT pneumococci in unvaccinated infants and this indirect effect likely originated from both the child and adult vaccinated populations.