D
David R. Meldrum
Researcher at University of California, Los Angeles
Publications - 131
Citations - 7443
David R. Meldrum is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Estrogen & Embryo transfer. The author has an hindex of 47, co-authored 131 publications receiving 7130 citations. Previous affiliations of David R. Meldrum include Salk Institute for Biological Studies & University of Naples Federico II.
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Journal ArticleDOI
Biologic effects of transdermal estradiol.
Ryszard J. Chetkowski,David R. Meldrum,Kenneth A. Steingold,Denise Randle,John K. H. Lu,Peter Eggena,Jerome M. Hershman,Norma Alkjaersig,Anthony P. Fletcher,Howard L. Judd +9 more
TL;DR: A dose–response study in 23 postmenopausal women to compare the physiologic effects of transdermal estradiol and oral conjugated equine estrogens found both preparations lowered gonadotropin levels, decreased the percentages of vaginal parabasal cells, increased the percentage of superficial cells, and lowered urinary calcium excretion.
Journal ArticleDOI
Oocyte environment: follicular fluid and cumulus cells are critical for oocyte health
Daniel A. Dumesic,David R. Meldrum,Mandy G. Katz-Jaffe,Rebecca L. Krisher,William B. Schoolcraft +4 more
TL;DR: Recent technologies are now exploring transcriptional, translational, and post-translational events within the human follicle with the goal of identifying biomarkers that reliably predict oocyte quality in the clinical setting.
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Association of Waking Episodes With Menopausal Hot Flushes
TL;DR: The data suggest the menopausal flushes are associated with a chronic sleep disturbance, and both can be improved by estrogen therapy.
Journal ArticleDOI
Blastocyst culture and transfer: analysis of results and parameters affecting outcome in two in vitro fertilization programs.
William B. Schoolcraft,David K. Gardner,Michelle Lane,Terry Schlenker,Fredesminda Hamilton,David R. Meldrum +5 more
TL;DR: Blastocyst culture and transfer is an effective means of treating patients who respond well to gonadotropins and high pregnancy rates can be accomplished with low numbers of embryos transferred.
Journal ArticleDOI
Steroid Secretion in Polycystic Ovarian Disease after Ovarian Suppression by a Long-Acting Gonadotropin- Releasing Hormone Agonist*
R. Jeffrey Chang,Larry R. Laufer,David R. Meldrum,John Defazio,John K. H. Lu,Wylie Vale,Jean Rivier,Howard L. Judd +7 more
TL;DR: In PCO subjects, GnRH-a induced complete suppression of ovarian steroid secretion, as circulating levels at the end of treatment were comparable to those seen in the authors' oophorectomy subjects, demonstrating that elevated A and T levels in PCO patients were derived primarily from the ovary.