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Showing papers in "Fertility and Sterility in 1999"


Journal ArticleDOI
TL;DR: The Fertility Problem Inventory provides a reliable measure of perceived infertility-related stress and specific information on five separate domains of patient concern and among patients receiving treatment, social, sexual, and relationship concerns appear central to current distress.

493 citations


Journal ArticleDOI
TL;DR: The advantage of selecting embryos with a normal chromosome complement has an immediate impact on the ongoing implantation rate, especially in patients aged > or =38 years and carriers of an altered karyotype.

440 citations


Journal ArticleDOI
TL;DR: The number of small antral follicles in both ovaries as measured by US is clearly related to reproductive age and could well reflect the size of the remaining primordial follicle pool.

382 citations


Journal ArticleDOI
TL;DR: Cryoloop vitrification was able to cryopreserve mouse and human blastocysts without any reduction in the ability to reexpand and hatch in culture and viability was not reduced.

370 citations


Journal ArticleDOI
TL;DR: The use of microsurgical fragment removal significantly alters the course of development for some embryos and improves their implanting potential, and adoption of an embryo classification system reflecting types of fragmentation is advisable.

351 citations


Journal ArticleDOI
TL;DR: A computerized pelvic mapping system for pelvic and intestinal endometriosis and preliminary insights gained from it with respect to the effects of ovarian disease suggest superficial or deep ovarian endometRIosis is a marker for the presence of more extensive pelvic and intestine disease.

344 citations


Journal ArticleDOI
TL;DR: Cornual resection or hysterectomy with a laparotomy should no longer be the first line of treatment for a hemodynamically stable patient with an interstitial pregnancy and in selected cases, methotrexate and laparoscopy can be used successfully in treating early interstitialregnancy.

340 citations


Journal ArticleDOI
TL;DR: The hypothesis that genes influence liability to endometriosis, supported by the findings of this Australia-wide volunteer sample of female monozygotic and dizygotic twins, is supported.

296 citations


Journal ArticleDOI
TL;DR: Blastocyst culture and transfer is an effective means of treating patients who respond well to gonadotropins and high pregnancy rates can be accomplished with low numbers of embryos transferred.

265 citations


Journal ArticleDOI
TL;DR: By reducing hyperinsulinism, metformin determines a reduction in intraovarian androgens, which leads to a Reduction in E2 levels and favors orderly follicular growth in response to exogenous gonadotropins.

242 citations


Journal ArticleDOI
TL;DR: Molecular aberrations that increase local E2 concentrations may be important in the etiology of endometriosis and these molecules may be targeted to develop novel therapeutic strategies.

Journal ArticleDOI
TL;DR: A basal 17-HP level is a useful screening tool for NCAH, with little loss in sensitivity if testing is performed in the morning and during the follicular phase, and a lower cutoff level (e.g., 2 or 3 ng/mL) is preferable ifTesting is performed at odd hours of the day, as is common in many practices, and maximum sensitivity is desired.

Journal ArticleDOI
TL;DR: Low-dose aspirin treatment significantly improves ovarian responsiveness, uterine and ovarian blood flow velocity, and implantation and pregnancy rates in IVF patients.

Journal ArticleDOI
TL;DR: Vascular endothelial growth factor seems to be the mediator of hCG on the vascular tree and there was an early systemic increase in VEGF that may have significance in the development of OHSS.

Journal ArticleDOI
TL;DR: Postcystectomy ovaries showed reduced follicular response in natural and CC-stimulated cycles for women < 35 years of age and produced a comparable number of follicles as normal ovaries when stimulated with gonadotropins.

Journal ArticleDOI
TL;DR: The results demonstrate the feasibility of using extended embryo culture in a nonselective manner for couples undergoing IVF, and the rate of multiple implantation among patients aged <35 years warrants consideration of single blastocyst transfers for this group.

Journal ArticleDOI
TL;DR: Antithyroid antibodies are identified more frequently in women with recurrent pregnancy loss than in controls but not in women undergoing ART, suggesting these autoantibodies may be markers of autoimmune activation and have been associated with an increased risk of pregnancy loss and postpartum thyroid disease.

Journal ArticleDOI
TL;DR: Tubal factor infertility was the most prominent risk factor for EP after IVF, and previous myomectomy appeared to be another important risk factor, but this is a new finding that needs to be confirmed by further study.

Journal ArticleDOI
TL;DR: The experience suggests that implantation and pregnancy rates are significantly reduced, and miscarriage rates may be increased in this group of patients, which comprise approximately 5% of the patients who undergo ET in this program.

Journal ArticleDOI
TL;DR: In women with PCOS and insulin resistance, the reduction of hyperinsulinemia that is produced by troglitazone improves the hyperandrogenism that characterizes PCOS, restoring ovulation.

Journal ArticleDOI
TL;DR: Testing the hypothesis that women with declining ovarian reserve may demonstrate a decrease in day 3 serum inhibin B levels before a rise in day3 serum FSH levels found that this finding was similar to those of women with nonovarian infertility.

Journal ArticleDOI
TL;DR: Insulin, androgens, and BMI are related in women both with PCOS and without PCOS, especially in obese ones, but obese women with PCos are more insulin-resistant, hyperandrogenic, and hypertriglyceridemic.

Journal ArticleDOI
TL;DR: Differences in patient characteristics and clinical and laboratory parameters in patients in whom ovarian hyperstimulation syndrome (OHSS) develops with those in whom it does not develop may be useful in elucidating the pathophysiology of OHSS and identifying patients who are at increased risk for OHSS.

Journal ArticleDOI
TL;DR: Chemokines play a relevant role in many physiologic and pathologic situations, such as ovulation, menstruation, implantation, cervical ripening and preterm labor, and endometriosis, and their regulation soon may provide new therapeutic strategies.

Journal ArticleDOI
TL;DR: Loxoribine, a potent immunomodulatory drug, appeared to cause regression in both stromal and epithelium components in a rat model of endometriosis.

Journal ArticleDOI
TL;DR: Laroscopic gynecologic surgery appears to be safe during pregnancy, although prospective controlled studies and national registries encompassing larger numbers of cases are needed.

Journal ArticleDOI
TL;DR: Low but detectable LH concentrations positively influence the outcome of ovulation induction in patients with ovulatory disorders and women undergoing assisted reproductive techniques.

Journal ArticleDOI
TL;DR: Many controlled ovarian hyperstimulation cycles are associated with synchronous early expression of the expected pattern of histologic features, estrogen and progesterone receptors, and pinopodes, and the most predictive feature of this premature expression was the level of progester one the day after hCG administration.

Journal ArticleDOI
TL;DR: The data suggest that factor V Leiden, thermolabile MTHFR (677C-->T), and prothrombin 20210G-->A are not found at an increased frequency in women with a history of early RPL.

Journal ArticleDOI
TL;DR: The sperm quality that is necessary for successful IUI is lower than World Health Organization threshold values for normal sperm, and intrauterine insemination is effective therapy for male factor infertility when initial sperm motility is < or = 30% and the total motile sperm count is > or = 5 X 10(6).