D
David R. Park
Researcher at University of Washington
Publications - 34
Citations - 2405
David R. Park is an academic researcher from University of Washington. The author has contributed to research in topics: Bronchoalveolar lavage & Lung injury. The author has an hindex of 24, co-authored 34 publications receiving 2264 citations. Previous affiliations of David R. Park include Harborview Medical Center.
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Journal ArticleDOI
Cytokine balance in the lungs of patients with acute respiratory distress syndrome.
William Y. Park,Richard B. Goodman,Kenneth P. Steinberg,John T. Ruzinski,Frank Radella,David R. Park,Jérôme Pugin,Shawn J. Skerrett,Leonard D. Hudson,Thomas R. Martin +9 more
TL;DR: The molar ratios remained low for 7 d or longer, limiting the activity of soluble IL-1 beta and TNF-alpha in the lungs at the onset of ARDS.
Journal Article
The microbiology of ventilator-associated pneumonia.
TL;DR: Information about the microbiology of VAP serves to guide optimal antibiotic therapy and the risk of antibiotic-resistant pathogens can be estimated using simple clinical features and awareness of local microbiology patterns.
Journal ArticleDOI
Fas (CD95) induces proinflammatory cytokine responses by human monocytes and monocyte-derived macrophages
David R. Park,Anni R. Thomsen,Charles W. Frevert,Uyenvy Pham,Shawn J. Skerrett,Peter A. Kiener,W. Conrad Liles +6 more
TL;DR: Rather than contributing to the resolution of inflammation, Fas ligation on circulating monocytes and tissue macrophages may induce proinflammatory cytokine responses that can initiate acute inflammatory responses and tissue injury.
Journal ArticleDOI
Use of the Medical Futility Rationale in Do-Not-Attempt-Resuscitation Orders
TL;DR: If the futility rationale is to be applied to withholding or withdrawing medical interventions, practice guidelines for its use should be developed, and education about medical futility must be incorporated into medical school, residency training, and continuing medical education programs.
Journal ArticleDOI
Essential Role of MMP-12 in Fas-Induced Lung Fibrosis
Gustavo Matute-Bello,Mark M. Wurfel,Janet S. Lee,David R. Park,Charles W. Frevert,David K. Madtes,Steven D. Shapiro,Thomas R. Martin +7 more
TL;DR: It is concluded that Fas activation in the lungs induces a complex response that includes apoptosis, inflammation, and eventually fibrosis, and that MMP-12 is essential for the fibrotic phenotype.