S
Steven D. Shapiro
Researcher at University of Pittsburgh
Publications - 332
Citations - 35490
Steven D. Shapiro is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Matrix metalloproteinase & Macrophage elastase. The author has an hindex of 96, co-authored 317 publications receiving 33615 citations. Previous affiliations of Steven D. Shapiro include Boston Medical Center & Barnes-Jewish Hospital.
Papers
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Journal ArticleDOI
MMP-9/Gelatinase B Is a Key Regulator of Growth Plate Angiogenesis and Apoptosis of Hypertrophic Chondrocytes
Thiennu H. Vu,J. Michael Shipley,Gabriele Bergers,Joel E. Berger,Jill A. Helms,Douglas Hanahan,Steven D. Shapiro,Robert M. Senior,Zena Werb +8 more
TL;DR: Transplantation of wild-type bone marrow cells rescues vascularization and ossification in gelatinase B-null growth plates, indicating that these processes are mediated by gelatinaseB-expressing cells of bone marrow origin, designated chondroclasts.
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Requirement for Macrophage Elastase for Cigarette Smoke-Induced Emphysema in Mice
TL;DR: Smoke-exposed MME-/- mice that received monthly intratracheal instillations of monocyte chemoattractant protein-1 showed accumulation of alveolar macrophages but did not develop air space enlargement, indicating that macrophage elastase is probably sufficient for the development of emphysema that results from chronic inhalation of cigarette smoke.
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Targeted gene disruption of matrix metalloproteinase-9 (gelatinase B) suppresses development of experimental abdominal aortic aneurysms
Robert Pyo,Jason K. Lee,J. Michael Shipley,John A. Curci,Dongli Mao,Scott J. Ziporin,Terri L. Ennis,Steven D. Shapiro,Robert M. Senior,Robert W. Thompson +9 more
TL;DR: It is shown that transient elastase perfusion of the mouse aorta results in delayed aneurysm development that is temporally associated with transmural mononuclear inflammation, increased local production of several elastolytic MMPs, and progressive destruction of the elastic lamellae, demonstrating that inflammatory cell expression of MMP-9 plays a critical role in an experimental model of aortic aneurYSm disease.
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Inhibition of plasminogen activators or matrix metalloproteinases prevents cardiac rupture but impairs therapeutic angiogenesis and causes cardiac failure.
Stephane Heymans,Aernout Luttun,Dieter Nuyens,Gregor Theilmeier,Esther E. Creemers,Lieve Moons,G D Dyspersin,Jack P.M. Cleutjens,M Shipley,A Angellilo,Marcel Levi,O Nübe,Andrew Baker,Eli Keshet,Florea Lupu,Jean-Marc Herbert,Jos F.M. Smits,Steven D. Shapiro,Myriam Baes,Marcel Borgers,Desire Collen,Mat J.A.P. Daemen,Peter Carmeliet +22 more
TL;DR: Temporary administration of PA inhibitor-1 or the matrix metalloproteinase-inhibitor TIMP-1 completely protected wild-type mice against rupture but did not abort infarct healing, thus constituting a new approach to prevent cardiac rupture after acute myocardial infarction.
Journal ArticleDOI
A randomized, controlled trial of protocol-directed versus physician-directed weaning from mechanical ventilation.
Marin H. Kollef,Steven D. Shapiro,Patricia Silver,Robert E. St. John,Donna Prentice,Sharon Sauer,Tom Ahrens,William D. Shannon,Darnetta Baker-Clinkscale +8 more
TL;DR: Protocol-guided weaning of mechanical ventilation, as performed by nurses and respiratory therapists, is safe and led to extubation more rapidly than physician-directed weaning.