J
Janet S. Lee
Researcher at University of Pittsburgh
Publications - 166
Citations - 6949
Janet S. Lee is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 42, co-authored 127 publications receiving 5643 citations. Previous affiliations of Janet S. Lee include University of Washington & Massachusetts Institute of Technology.
Papers
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Journal ArticleDOI
Cytokine-mediated inflammation in acute lung injury.
TL;DR: A recent multi-center clinical trial found that a lung-protective ventilatory strategy reduces mortality by 22% in patients with ALI and was associated with a marked reduction in the number of neutrophils and the concentration of pro-inflammatory cytokines released into the airspaces of the injured lung.
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Nitric oxide scavenging by red blood cell microparticles and cell-free hemoglobin as a mechanism for the red cell storage lesion.
Chenell Donadee,Nicolaas J.H. Raat,Tamir Kanias,Jesús Tejero,Janet S. Lee,Eric E. Kelley,Xuejun Zhao,Chen Liu,Hannah Reynolds,Ivan Azarov,Sheila Frizzell,E. Michael Meyer,Albert D. Donnenberg,Lirong Qu,Darrel Triulzi,Daniel B. Kim-Shapiro,Mark T. Gladwin +16 more
TL;DR: Two complementary in vivo studies suggest new mechanisms for endothelial injury and impaired vascular function associated with the most fundamental of storage lesions, hemolysis.
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Egr-1 Regulates Autophagy in Cigarette Smoke-Induced Chronic Obstructive Pulmonary Disease
Zhi Hua Chen,Hong Pyo Kim,Hong Pyo Kim,Frank C. Sciurba,Seon Jin Lee,Seon Jin Lee,Carol Feghali-Bostwick,Donna B. Stolz,Rajiv Dhir,Rodney J. Landreneau,Mathew J. Schuchert,Samuel A. Yousem,Kiichi Nakahira,Kiichi Nakahira,Joseph M. Pilewski,Janet S. Lee,Yingze Zhang,Stefan W. Ryter,Stefan W. Ryter,Augustine M.K. Choi +19 more
TL;DR: A critical role for Egr-1 is demonstrated in promoting autophagy and apoptosis in response to cigarette smoke exposure in vitro and in vivo, suggesting novel therapeutic targets for the treatment of cigarette smoke induced lung injury.
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PINK1 deficiency impairs mitochondrial homeostasis and promotes lung fibrosis
Marta Bueno,Yen-Chun Lai,Yair Romero,Judith Brands,Claudette M. St. Croix,Christelle Kamga,Catherine Corey,Jose D. Herazo-Maya,John Sembrat,Janet S. Lee,Steve R. Duncan,Mauricio Rojas,Sruti Shiva,Charleen T. Chu,Ana L. Mora +14 more
TL;DR: The data indicate that PINK1 deficiency results in swollen, dysfunctional mitochondria and defective mitophagy, and promotes fibrosis in the aging lung, as well as in normal mice with advancing age.
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Mitochondrial localization and function of heme oxygenase-1 in cigarette smoke-induced cell death.
Dirk-Jan Slebos,Stefan W. Ryter,Marco van der Toorn,Fang Liu,Fengli Guo,Catherine J. Baty,Jenny M. Karlsson,Simon C. Watkins,Hong Pyo Kim,Xue Wang,Janet S. Lee,Dirkje S. Postma,Henk F. Kauffman,Augustine M.K. Choi +13 more
TL;DR: The functional compartmentalization of heme oxygenase-1 in the mitochondria of lung epithelial cells, and its potential role in defense against mitochondria-mediated cell death during CSE exposure are demonstrated.