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David Rouquié
Researcher at Bayer
Publications - 27
Citations - 1519
David Rouquié is an academic researcher from Bayer. The author has contributed to research in topics: Flutamide & Toxicity. The author has an hindex of 13, co-authored 25 publications receiving 1266 citations. Previous affiliations of David Rouquié include Utrecht University & University of Tübingen.
Papers
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Journal ArticleDOI
Polar PIN localization directs auxin flow in plants.
Justyna Wiśniewska,Jian Xu,Jian Xu,Daniela Seifertová,Daniela Seifertová,Philip B. Brewer,Philip B. Brewer,Kamil Růžička,Kamil Růžička,Ikram Blilou,Ikram Blilou,David Rouquié,David Rouquié,Eva Benková,Eva Benková,Ben Scheres,Ben Scheres,Jiri Friml,Jiri Friml +18 more
TL;DR: Interfering with sequence-embedded polarity signals directly demonstrates that PIN polarity is a primary factor in determining the direction of auxin flow in meristematic tissues.
Journal ArticleDOI
De novo generation of hit-like molecules from gene expression signatures using artificial intelligence
TL;DR: A generative model that bridges systems biology and molecular design, conditioning a generative adversarial network with transcriptomic data that can automatically design molecules that have a high probability to induce a desired transcriptomic profile.
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Safety evaluation of the double mutant 5-enol pyruvylshikimate-3-phosphate synthase (2mEPSPS) from maize that confers tolerance to glyphosate herbicide in transgenic plants.
Corinne Herouet-Guicheney,David Rouquié,Martine Freyssinet,Thomas Currier,Aris Martone,Junguo Zhou,Elizabeth E.M. Bates,Jean-Marc Ferullo,Koen Hendrickx,Dominique Rouan +9 more
TL;DR: There is a reasonable certainty of no harm resulting from the inclusion of the 2mEPSPS protein in human food or in animal feed.
Journal ArticleDOI
Liver tumor formation in female rat induced by fluopyram is mediated by CAR/PXR nuclear receptor activation.
TL;DR: Fluopyram is a threshold carcinogen and the resultant hepatocellular carcinomas in the female rat are due to hepato cellular proliferation mediated by CAR/PXR activation.
Journal ArticleDOI
Thyroid tumor formation in the male mouse induced by fluopyram is mediated by activation of hepatic CAR/PXR nuclear receptors.
TL;DR: Fluopyram thyroid toxicity is mediated by activation of hepatic Car/Pxr receptors and shows a threshold dependent MOA, which leads to hyperplasia and eventually adenomas after chronic exposure.