D
David Sagnat
Researcher at University of Toulouse
Publications - 6
Citations - 73
David Sagnat is an academic researcher from University of Toulouse. The author has contributed to research in topics: Inflammation & Thrombin. The author has an hindex of 3, co-authored 4 publications receiving 36 citations. Previous affiliations of David Sagnat include French Institute of Health and Medical Research.
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Journal ArticleDOI
Active thrombin produced by the intestinal epithelium controls mucosal biofilms
Jean-Paul Motta,Alexandre Denadai-Souza,David Sagnat,Laura Guiraud,Anissa Edir,Chrystelle Bonnart,Mireille Sebbag,Perrine Rousset,Ariane Lapeyre,Carine Seguy,Noa Mathurine-Thomas,Heather J. Galipeau,Delphine Bonnet,Laurent Alric,Andre G. Buret,John L. Wallace,Antoine Dufour,Elena F. Verdu,Morley D. Hollenberg,Eric Oswald,Matteo Serino,Céline Deraison,Nathalie Vergnolle,Nathalie Vergnolle +23 more
TL;DR: It is shown that the commensal microbiota modulates epithelial production of active thrombin, which controls biofilm growth and contributes to protection of the mucosa from bacterial invasion.
Journal ArticleDOI
Increased Mucosal Thrombin is Associated with Crohn's Disease and Causes Inflammatory Damage through Protease-activated Receptors Activation
Jean-Paul Motta,Simone Palese,Simone Palese,Carmine Giorgio,Carmine Giorgio,Kevin Chapman,Alexandre Denadai-Souza,Perrine Rousset,David Sagnat,Laura Guiraud,Anissa Edir,Carine Seguy,Laurent Alric,Delphine Bonnet,Barbara Bournet,Louis Buscail,Cyrielle Gilletta,Andre G. Buret,John L. Wallace,Morley D. Hollenberg,Eric Oswald,Elisabetta Barocelli,Sylvie Le Grand,Bruno Le Grand,Céline Deraison,Nathalie Vergnolle,Nathalie Vergnolle +26 more
TL;DR: It is demonstrated that increased local thrombin activity, as it occurs in the colon of patients with inflammatory bowel disease, causes mucosal damage and inflammation.
Journal ArticleDOI
Epithelial production of elastase is increased in inflammatory bowel disease and causes mucosal inflammation.
Jean-Paul Motta,Corinne Rolland,Anissa Edir,Ana Carolina Rodrigues Florence,David Sagnat,Chrystelle Bonnart,Perrine Rousset,Laura Guiraud,Muriel Quaranta-Nicaise,Emmanuel Mas,Delphine Bonnet,Elena F. Verdu,Derek M. McKay,Etienne Buscail,Laurent Alric,Nathalie Vergnolle,Nathalie Vergnolle,Céline Deraison +17 more
TL;DR: ELA2A appears as a novel actor produced by intestinal epithelial cells, which can drive inflammation and loss of barrier function, two essentials pathophysiological hallmarks of IBD, and should be considered as a potential target for IBD treatment.
Journal ArticleDOI
Sexual dimorphism in PAR2-dependent regulation of primitive colonic cells
Julie Noguerol,Pierre-Jean Roustan,Mikael N’Taye,Léo Delcombel,Corinne Rolland,Laura Guiraud,David Sagnat,Anissa Edir,Chrystelle Bonnart,Alexandre Denadai-Souza,Céline Deraison,Nathalie Vergnolle,Claire Racaud-Sultan +12 more
TL;DR: There is a sexual dimorphism in the PAR2-dependent regulation of primitive cells of the colon crypt, which controlled the gene expression and activation of key negative signals of the primitive cell proliferation.
Journal ArticleDOI
Daphnanes diterpenes from the latex of Hura crepitans L. and their PKCζ-dependent anti-proliferative activity on colorectal cancer cells.
Elise Crossay,Valérie Jullian,Manon Trinel,David Sagnat,Dimitri Hamel,Corinne Rolland,Jean-Luc Stigliani,Kember Mejia,Billy Cabanillas,Laurent Alric,Etienne Buscail,Chaker El Kalamouni,Patrick Mavingui,Céline Deraison,Claire Racaud-Sultan,Nicolas Fabre +15 more
TL;DR: In this article , a fractionation of a dichloromethane extract of the latex led to the isolation of five new daphnane-type diterpenes (1-5), along with two known analogs (6-7) including huratoxin.