K
Kevin Chapman
Researcher at University of Calgary
Publications - 28
Citations - 3104
Kevin Chapman is an academic researcher from University of Calgary. The author has contributed to research in topics: Hyperalgesia & Colitis. The author has an hindex of 22, co-authored 28 publications receiving 2841 citations.
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Journal ArticleDOI
Role for protease activity in visceral pain in irritable bowel syndrome.
Nicolas Cenac,Christopher N. Andrews,Marinella Holzhausen,Kevin Chapman,Graeme S. Cottrell,Patricia Andrade-Gordon,Martin Steinhoff,Giovanni Barbara,Paul L. Beck,Nigel W. Bunnett,Keith A. Sharkey,Jose G. Ferraz,Eldon A. Shaffer,Nathalie Vergnolle +13 more
TL;DR: It is established that proteases are released in IBS and that they can directly stimulate sensory neurons and generate hypersensitivity symptoms through the activation of PAR2.
Journal ArticleDOI
Increased gelatinase A (MMP-2) and gelatinase B (MMP-9) activities in human brain after focal ischemia
TL;DR: Different temporal profiles of post-ischemic gelatinase activity in human brain are indicated, with earlier but equally persistent elevation in gelatinase B when compared to gelatinase A.
Journal ArticleDOI
Protease‐activated receptor 2 sensitizes TRPV1 by protein kinase Cɛ‐ and A‐dependent mechanisms in rats and mice
Silvia Amadesi,Graeme S. Cottrell,Lorna Divino,Kevin Chapman,Eileen F. Grady,Francisco Bautista,Rustum Karanjia,Carlos Barajas-López,Stephen J. Vanner,Nathalie Vergnolle,Nigel W. Bunnett +10 more
TL;DR: PAR2 activates protein kinase Cɛ and PKA in sensory neurons, and thereby sensitizes TRPV1 to cause thermal hyperalgesia, which may underlie inflammatory pain.
Journal ArticleDOI
Food-Grade Bacteria Expressing Elafin Protect Against Inflammation and Restore Colon Homeostasis
Jean-Paul Motta,Luis G. Bermúdez-Humarán,Céline Deraison,Céline Deraison,Céline Deraison,Laurence Martin,Laurence Martin,Laurence Martin,Corinne Rolland,Corinne Rolland,Corinne Rolland,Perrine Rousset,Perrine Rousset,Perrine Rousset,Jérôme Boué,Jérôme Boué,Jérôme Boué,Gilles Dietrich,Gilles Dietrich,Gilles Dietrich,Kevin Chapman,Pascale Kharrat,Jean-Pierre Vinel,Laurent Alric,Emmanuel Mas,Jean-Michel Sallenave,Jean-Michel Sallenave,Jean-Michel Sallenave,Philippe Langella,Nathalie Vergnolle +29 more
TL;DR: Oral treatment with Elafin-expressing food-grade bacteria protected the gut from inflammatory damage and restored intestinal homeostasis in mouse models of acute and chronic colitis, and suggested that oral delivery of LAB secreting ElafIn may be useful for treating IBD in humans.
Journal ArticleDOI
Transient receptor potential vanilloid-4 has a major role in visceral hypersensitivity symptoms.
Nicolas Cenac,Nicolas Cenac,Nicolas Cenac,Christophe Altier,Kevin Chapman,Wolfgang Liedtke,Gerald W. Zamponi,Nathalie Vergnolle,Nathalie Vergnolle,Nathalie Vergnolle +9 more
TL;DR: 4alphaPDD selectively activates TRPV4 in sensory neurons projecting from the colon, and TRPv4 activation causes visceral hypersensitivity, suggesting a pivotal role for TRP V4 in visceral nociception and hypersensitivity.