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Alexandre Denadai-Souza
Researcher at University of Toulouse
Publications - 31
Citations - 723
Alexandre Denadai-Souza is an academic researcher from University of Toulouse. The author has contributed to research in topics: Inflammation & Proteases. The author has an hindex of 12, co-authored 27 publications receiving 489 citations. Previous affiliations of Alexandre Denadai-Souza include University of São Paulo & Katholieke Universiteit Leuven.
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Journal ArticleDOI
Local immune response to food antigens drives meal-induced abdominal pain
Javier Aguilera-Lizarraga,Morgane Florens,Maria Francesca Viola,Piyush Jain,Lisse Decraecker,Iris Appeltans,Maria Cuende-Estevez,Naomi Fabre,Kim Van Beek,Eluisa Perna,Dafne Balemans,Nathalie Stakenborg,Stavroula Theofanous,Goele Bosmans,Stephanie Mondelaers,Gianluca Matteoli,Sales Ibiza Martínez,Sales Ibiza Martínez,Cintya Lopez-Lopez,Josue Jaramillo-Polanco,Karel Talavera,Yeranddy A. Alpizar,Thorsten B. Feyerabend,Hans-Reimer Rodewald,Ricard Farré,Frank A. Redegeld,Jiyeon Si,Jeroen Raes,Christine Breynaert,Rik Schrijvers,Cedric Bosteels,Bart N. Lambrecht,Bart N. Lambrecht,Scott D. Boyd,Ramona A. Hoh,Deirdre Cabooter,Maxim Nelis,Patrick Augustijns,Sven Hendrix,Jessica Strid,Raf Bisschops,David E. Reed,Stephen Vanner,Alexandre Denadai-Souza,Mira M. Wouters,Guy E. Boeckxstaens +45 more
TL;DR: In this article, the authors identify and characterize a peripheral mechanism that underlies food-induced abdominal pain, thereby creating new possibilities for the treatment of irritable bowel syndrome and related abdominal pain disorders.
Journal ArticleDOI
Differing effects of exogenous and endogenous hydrogen sulphide in carrageenan-induced knee joint synovitis in the rat.
Eduardo Ekundi-Valentim,Karen Tiago dos Santos,Edson Amaral Camargo,Edson Amaral Camargo,Alexandre Denadai-Souza,Simone A. Teixeira,Cristiane I. Zanoni,Andrew D. Grant,John L. Wallace,Marcelo Nicolas Muscará,Soraia K.P. Costa +10 more
TL;DR: Evaluated the ability of endogenous and exogenous H2S to modulate carrageenan‐induced synovitis in the rat knee and found that both concentrations are able to modulates pain and inflammation in rodents.
Journal ArticleDOI
Epithelial expression and function of trypsin-3 in irritable bowel syndrome
Claire Rolland-Fourcade,Alexandre Denadai-Souza,Carla Cirillo,Cintya D. Lopez Lopez,Josue Obed Jaramillo,Cleo Desormeaux,Nicolas Cenac,Jean-Paul Motta,Muriel H. Larauche,Yvette Taché,Pieter Vanden Berghe,Michel Neunlist,Emmanuel Coron,Sylvain Kirzin,Guillaume Portier,Delphine Bonnet,Laurent Alric,Stephen Vanner,Céline Deraison,Nathalie Vergnolle,Nathalie Vergnolle +20 more
TL;DR: In IBS, the intestinal epithelium produces and releases the active protease trypsin-3, which is able to signal to enteric neurons and to induce visceral hypersensitivity.
Journal ArticleDOI
Functional Proteomic Profiling of Secreted Serine Proteases in Health and Inflammatory Bowel Disease
Alexandre Denadai-Souza,Chrystelle Bonnart,Nuria Sola Tapias,Marlène Marcellin,Brendan Gilmore,Laurent Alric,Delphine Bonnet,Odile Burlet-Schiltz,Morley D. Hollenberg,Nathalie Vergnolle,Nathalie Vergnolle,Céline Deraison +11 more
TL;DR: The functional ABP-targeted proteomic approach that is used to identify active proteases in human colonic samples bears directly on the understanding of the role these enzymes may play in the pathophysiology of IBD.
Journal ArticleDOI
Participation of peripheral tachykinin NK1 receptors in the carrageenan-induced inflammation of the rat temporomandibular joint.
Alexandre Denadai-Souza,Livia L Camargo,Maria Teresa C.P. Ribela,Julie Keeble,Soraia K.P. Costa,Marcelo Nicolas Muscará +5 more
TL;DR: The results obtained from the present TMJ‐arthritis model provide, for the first time, information regarding the time course of this experimental inflammatory process and show that peripheral NK1 receptors mediate the production of both TNFα and IL‐1β in the TMJ as well as some of the inflammatory signs, such as plasma extravasation and leukocyte influx, but not the nociceptive component.