P
Perrine Rousset
Researcher at University of Toulouse
Publications - 20
Citations - 931
Perrine Rousset is an academic researcher from University of Toulouse. The author has contributed to research in topics: Inflammation & Colitis. The author has an hindex of 10, co-authored 16 publications receiving 767 citations. Previous affiliations of Perrine Rousset include Paul Sabatier University & Centre national de la recherche scientifique.
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Journal ArticleDOI
Food-Grade Bacteria Expressing Elafin Protect Against Inflammation and Restore Colon Homeostasis
Jean-Paul Motta,Luis G. Bermúdez-Humarán,Céline Deraison,Céline Deraison,Céline Deraison,Laurence Martin,Laurence Martin,Laurence Martin,Corinne Rolland,Corinne Rolland,Corinne Rolland,Perrine Rousset,Perrine Rousset,Perrine Rousset,Jérôme Boué,Jérôme Boué,Jérôme Boué,Gilles Dietrich,Gilles Dietrich,Gilles Dietrich,Kevin Chapman,Pascale Kharrat,Jean-Pierre Vinel,Laurent Alric,Emmanuel Mas,Jean-Michel Sallenave,Jean-Michel Sallenave,Jean-Michel Sallenave,Philippe Langella,Nathalie Vergnolle +29 more
TL;DR: Oral treatment with Elafin-expressing food-grade bacteria protected the gut from inflammatory damage and restored intestinal homeostasis in mouse models of acute and chronic colitis, and suggested that oral delivery of LAB secreting ElafIn may be useful for treating IBD in humans.
Journal ArticleDOI
LC-MS/MS method for rapid and concomitant quantification of pro-inflammatory and pro-resolving polyunsaturated fatty acid metabolites.
Pauline Le Faouder,Vincent Baillif,I. Spreadbury,Jean-Paul Motta,Jean-Paul Motta,Jean-Paul Motta,Perrine Rousset,Perrine Rousset,Perrine Rousset,Gerald Chene,Charlotte Guigné,François Tercé,François Tercé,Stephen J. Vanner,Nathalie Vergnolle,Nathalie Vergnolle,Nathalie Vergnolle,Justine Bertrand-Michel,Justine Bertrand-Michel,Marc Dubourdeau,Nicolas Cenac,Nicolas Cenac,Nicolas Cenac +22 more
TL;DR: In this article, a simple methodology using liquid chromatography-tandem mass spectrometry allowing quantification of low-level PUFA metabolites including bioactive mediators, inactive products and pathway biomarkers was developed.
Journal ArticleDOI
Transient Receptor Potential Vanilloid 4 Activated Inflammatory Signals by Intestinal Epithelial Cells and Colitis in Mice
Emilie d'Aldebert,Emilie d'Aldebert,Nicolas Cenac,Nicolas Cenac,Perrine Rousset,Perrine Rousset,Laurence Martin,Laurence Martin,Corinne Rolland,Corinne Rolland,Kevin Chapman,Janick Selves,Laurent Alric,Jean-Pierre Vinel,Nathalie Vergnolle,Nathalie Vergnolle,Nathalie Vergnolle +16 more
TL;DR: TRPV4 is expressed and functional in intestinal epithelial cells; its activation in the gastrointestinal tract causes increases in intracellular calcium concentrations, chemokine release, and colitis.
Journal ArticleDOI
Modifying the protease, antiprotease pattern by elafin overexpression protects mice from colitis.
Jean-Paul Motta,Jean-Paul Motta,Jean-Paul Motta,Laurent Magne,Laurent Magne,Delphyne Descamps,Delphyne Descamps,Corinne Rolland,Corinne Rolland,Corinne Rolland,Camila Squarzoni Dale,Camila Squarzoni Dale,Camila Squarzoni Dale,Perrine Rousset,Perrine Rousset,Perrine Rousset,Laurence Martin,Laurence Martin,Laurence Martin,Nicolas Cenac,Nicolas Cenac,Nicolas Cenac,Viviane Balloy,Viviane Balloy,Michel Huerre,Leopold F. Fröhlich,Dieter E. Jenne,Julien Wartelle,Azzaq Belaaouaj,Emmanuel Mas,Jean-Pierre Vinel,Laurent Alric,Michel Chignard,Michel Chignard,Nathalie Vergnolle,Nathalie Vergnolle,Nathalie Vergnolle,Jean-Michel Sallenave,Jean-Michel Sallenave +38 more
TL;DR: The role of elafin, a serine protease inhibitor expressed by skin and mucosal surfaces in human inflammatory conditions, and the proteases neutrophil elastase (NE) and proteinase-3 (PR-3) in mice with colitis was investigated in this paper.
Journal ArticleDOI
Protective Role for Protease-Activated Receptor-2 against Influenza Virus Pathogenesis via an IFN-γ-Dependent Pathway
Khaled Khoufache,Fanny LeBouder,Eric Morello,Fabrice Laurent,Sabine Riffault,Patricia Andrade-Gordon,Séverine Boullier,Perrine Rousset,Nathalie Vergnolle,Béatrice Riteau +9 more
TL;DR: It is shown that PAR2 plays a protective role during IAV infection through IFN-γ production and decreased excessive recruitment of inflammatory cells to lung alveoli and in bronchoalveolar lavages.