D
David Spaner
Researcher at Sunnybrook Health Sciences Centre
Publications - 69
Citations - 4100
David Spaner is an academic researcher from Sunnybrook Health Sciences Centre. The author has contributed to research in topics: Chronic lymphocytic leukemia & Antigen. The author has an hindex of 22, co-authored 66 publications receiving 3724 citations. Previous affiliations of David Spaner include Women's College, Kolkata & University of Toronto.
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Journal ArticleDOI
Chemotherapy-Refractory Diffuse Large B-Cell Lymphoma and Indolent B-Cell Malignancies Can Be Effectively Treated With Autologous T Cells Expressing an Anti-CD19 Chimeric Antigen Receptor
James N. Kochenderfer,Mark E. Dudley,Sadik H. Kassim,Robert Somerville,Robert O. Carpenter,Maryalice Stetler-Stevenson,James Chih-Hsin Yang,Giao Q. Phan,Michael S. Hughes,Richard M. Sherry,Mark Raffeld,Steven R. Feldman,Lily Lu,Yong F. Li,Lien T. Ngo,Andre Goy,Tatyana Feldman,David Spaner,Michael L. Wang,Clara C. Chen,Sarah M. Kranick,Avindra Nath,Debbie-Ann N. Nathan,Kathleen E. Morton,Mary Ann Toomey,Steven A. Rosenberg +25 more
TL;DR: The results demonstrate the feasibility and effectiveness of treating chemotherapy-refractory B-cell malignancies with anti-CD19 CAR T cells and provide strong support for further development of this approach.
Journal ArticleDOI
B-cell depletion and remissions of malignancy along with cytokine-associated toxicity in a clinical trial of anti-CD19 chimeric-antigen-receptor–transduced T cells
James N. Kochenderfer,Mark E. Dudley,Steven A. Feldman,Wyndham H. Wilson,David Spaner,Irina Maric,Maryalice Stetler-Stevenson,Giao Q. Phan,Michael S. Hughes,Richard M. Sherry,James Chih-Hsin Yang,Udai S. Kammula,Laura Devillier,Robert J. Carpenter,Debbie Ann N. Nathan,Richard A. Morgan,Carolyn M. Laurencot,Steven A. Rosenberg +17 more
TL;DR: Pro adoptive transfer of T cells genetically modified to express an anti-CD19 chimeric Ag receptor (CAR) has great promise to improve the treatment of B-cell malignancies because of a potent ability to eradicate CD19(+) cells in vivo; however, reversible cytokine-associated toxicities occurred after CAR-transduced T-cell infusions.
Journal ArticleDOI
Intensive chemotherapy and autologous stem-cell transplantation plus rituximab is superior to conventional chemotherapy for newly diagnosed advanced stage mantle-cell lymphoma: a matched pair analysis
Joy Mangel,Heather A. Leitch,Jean M. Connors,Rena Buckstein,K. Imrie,David Spaner,Michael Crump,Nancy Pennell,A. Boudreau,Neil Berinstein +9 more
TL;DR: This matched-pair analysis suggests that patients with advanced-stage MCL treated with ASCT-rituximab had statistically significantly better PFS and a trend toward better OS than patients treated with conventional chemotherapy.
Journal ArticleDOI
Comprehensive Lipidomics Analysis of Bioactive Lipids in Complex Regulatory Networks
TL;DR: The method allowed us to examine eicosanoid profiles within the signaling cascade in chronic lymphocytic leukemia (CLL) cells under basal conditions and following arachidonic acid stimulation, and demonstrated that the performance of the assay was very similar to that of a quadrupole linear ion trap assay.
Journal Article
Chronic Lymphocytic Leukemia-reactive T Cells during Disease Progression and after Autologous Tumor Cell Vaccines
Elena Gitelson,Caitlin Hammond,Jenny Mena,Maria Lorenzo,Rena Buckstein,Neil L. Berinstein,Kevin Imrie,David Spaner +7 more
TL;DR: Tumor-reactive T cells exist in some CLL patients and may potentially mediate therapeutic responses if their numbers and activation states can be sufficiently increased by tumor vaccines.